Modeling order-disorder transition in Low-Density Lipoprotein

Abstract

Abstract-Low Density Lipoproteins (LDL) undergo a reversible order-disorder thermal transition close to biological temperature due to cooperative melting of the cholesteryl esters (CE) in the core of the LDL particle. We have noticed that chain-chain interactions between CE molecules are responsible for the stability of the ordered smectic phase; thus, we formulated a simple "coarse-grained" two-state model to describe the melting process. In this model only nearest neighbor interactions are allowed. On the basis of these assumptions we performed Metropolis Monte Carlo (MC) simulation in order to obtain the heat capacity curve. The resulting profile reveals well-known features of the systems with a finite size.

Analysis of Gender Difference on Online Shopping Lifestyle at Padang City

“…According to Zhou et al, (2007) suggest three explanations for gender differences in online shopping. First, women's shopping orientation is different from that of men.…”

“…Finally, women prefer and enjoy physical evaluation of products such as seeing and feeling the product before they buy it (Dittmar et al, 2004). Furthermore, literature reviews of online shopping indicate that results concerning gender differences in online shopping environments are mixed and inconsistent (Chang et al, 2005;Zhou et al, 2007). As a result, little is known about males and females perceptions of online shopping and what impacts men's and women's decision to engage in or abstain from online shopping (Cyr & Bonanni, 2005).…”

“…According to Chang et al, (2005) shows that more men than women buying online in some studies and no significant gender differences in online shopping behaviour between the genders in other studies. Likewise, according to Zhou et al, (2007) demonstrates conflicting findings pertaining to the impact of gender on online shopping activities. Thus, gender differences in online shopping lifestyle deserve more attention and better understanding.…”

Adsorption of Low Density Lipoproteins on an Azobenzene-Containing Polymer Brush: Modelling by Coarse-Grained Molecular Dynamics

“…One should note that the native length scale of the problem, complexity, and ambiguity of the LDL structure [2,[22][23][24][25][26][27][28][29] prevent performing atomistic-scale simulation of such a process in the foreseen future. There are a number of computer simulation studies performed mostly on a coarse-grained level that address the structure of LDL, lipid transport, receptor mutations, and other related topics [30][31][32][33][34][35][36][37][38][39].…”