Modeling of restenosis of main arteries after the intravascular stenting interventions

Germanova, Olga; Germanov, Vladimir; Shchukin, Yurii V.; Щукин, Ю. В.; Germanov, Andrey; Piskunov, Maxim V.; Piskunov, Maxim; Burmistrov, Andrei E.; Бурмистров, А Е; Yusupov, Rinat Yu.; Юсупов, Р Ю; Galati, Giuseppe; Дж., Галати

doi:10.35693/2500-1388-2021-6-1-45-49

Cited by 2 publications

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“…In our previous publications, we wrote about the increase in the main factors of the kinetics of the main arteries during the spread of the first post-extrasystolic wave [20][21][22][23]. So, we used the experimental modeling to confirm the clinical results.…”

Section: Discussionmentioning

confidence: 99%

Modeling of Restenosis on Implanted Intra-Arterial Stent in Experimental Cardiology

Germanova¹,

Fedorina²,

Germanov³

et al. 2022

ArveMED

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Aim of investigation is to study the features of the mechanism of restenosis on implanted intravascular stent, using the original device for modeling of intra-arterial circulation. Materials and methods. We use an original device for modeling intra-arterial circulation (document of invention RU 202780). It is a simulation of arterial vessel, made of glass tube rotameter. Its free ends are connected with two silicone tubes, with other ends - to the pump, powered by a 12 Volt battery. We injected the fluid (an aqueous solution of glycerin) into the closed system, diluted corresponding to the viscosity of human blood. A fitting is located at the inlet end of the tube, through which we can introduce a dye (ink), a silk thread or intravascular pressure probe inside the tube. Results. As a prototype of intravascular endoprosthesis, we used a metal device 71 mm length, made in the form of a grid with beams directed in a spiral. We installed a conductor with a 5 cm long silk thread inside the endoprosthesis. The pump works simulating the regular heart rhythm or premature ventricular contractions. We observed an intense pressure effect of the first post-extrasystolic wave on the rotameter tube, with the formation of reflected, standing waves (the pressure increased by 160% compared with the regular heart rhythm). Conclusion. With the spread of the first post-extrasystolic wave, a “hydraulic shock” occurs in the arterial vessel. Its mechanical effect can be the starting point for the onset and progression of restenosis in an implanted intravascular stent.

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Section: Discussionmentioning

confidence: 99%

Modeling of Restenosis on Implanted Intra-Arterial Stent in Experimental Cardiology

Germanova¹,

Fedorina²,

Germanov³

et al. 2022

ArveMED

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“…In our clinical practice, we observed changes in the hemodynamic parameters measured by methods of Doppler ultrasound imaging and digital sphygmography in different arrhythmias (for example, extrasystoles, atrial fibrillation) [10][11][12][13]. To confirm the revealed pattern, we have created an original experimental device for modeling of intra-arterial circulation.…”

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confidence: 99%

Modeling of Intra-Arterial Circulation: Application in Experimental Cardiology

Germanova¹,

Galati²,

Usenova³

et al. 2022

ArveMED

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im of our investigation is to evaluate the use of the device for modeling of intra-arterial circulation and substantiate the possibility of its use in experimental cardiology. Materials and methods. The principle part of the model is the cone-shaped narrowed glass cylinder 365 mm long with an inlet diameter of 20 mm, an outlet diameter of 16,5 mm. Two-way fitting with a rubber valve is screwed from the input side. Flexible silicone tubes are attached to both sides of the cylinder, with the other end attached to an electric water pump. The water pump is connected with 12 Volt battery. In one of the outer corners, we insert a needle for introducing dyes (clerical ink) and a silk thread through the fitting valve into the glass tube. We filled the closed circuit with an aqueous solution of glycerin, the viscosity of which was similar to the blood. The water pump provides continuous or intermittent circulation of the glycerin solution in a closed system. We observed the thread movements and turbulent flow colored by the ink during the spread of the pulse waves. Results. We simulated the pulse waves occurring in the regular heart rhythm, as well as arrhythmias. When simulating the extrasystoles, we observed a turbulent fluid flow during the spread of the 1st post-extrasystolic wave behind the installed diaphragm. With the spreading of the 1st post-extrasystolic wave, the pressure level inside the tube is increased in comparison with the regular rhythm. Conclusion. Device for modeling of intra-arterial circulation is simple and reliable in its construction. It imitates the intra-arterial processes in different hemodynamic situations, such as regular heart rhythm, arrhythmias, and atherosclerotic plaques. It can be used in the wide spectrum of experimental works in cardiology, vascular surgery, physiology, pathophysiology, biophysics.

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Modeling of restenosis of main arteries after the intravascular stenting interventions

Cited by 2 publications

References 1 publication

Modeling of Restenosis on Implanted Intra-Arterial Stent in Experimental Cardiology

Modeling of Restenosis on Implanted Intra-Arterial Stent in Experimental Cardiology

Modeling of Intra-Arterial Circulation: Application in Experimental Cardiology

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