Modeling of nanoparticle transport through the female reproductive tract for the treatment of infectious diseases

Sims, Lee B.; Miller, Hunter A.; Halwes, Michael E.; Steinbach-Rankins, Jill M.; Frieboes, Hermann B.

doi:10.1016/j.ejpb.2018.09.003

Cited by 6 publications

(4 citation statements)

References 54 publications

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“…As a complementary tool to the experimental researches, mathematical modeling and computational simulation have been recently proposed to provide a systematic evaluation of NPs transport through female reproductive tract. The aim of this approach was to offer a powerful platform to point the experimental efforts towards the optimization of NPs penetration [30].…”

Section: Mucus-penetrating Nanoparticles (Mpnps)mentioning

confidence: 99%

Recent advances in the mucus-interacting approach for vaginal drug delivery: from mucoadhesive to mucus-penetrating nanoparticles

Rossi

Vigani

Sandri

et al. 2019

Expert Opinion on Drug Delivery

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Section: Mucus-penetrating Nanoparticles (Mpnps)mentioning

confidence: 99%

Recent advances in the mucus-interacting approach for vaginal drug delivery: from mucoadhesive to mucus-penetrating nanoparticles

Rossi

Vigani

Sandri

et al. 2019

Expert Opinion on Drug Delivery

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“…A promising approach overcoming this drawback seems to derive from "stealth" NPs. In a study by Sims et al (2019), stealth PEG-coated NPs exhibited appropriate mucus-penetrating properties as well as improved drug retention and transport. Tests performed on PLGA NPs showed that prolonged retention profiles for 24 h were obtained with the greatest percentage of PEG coating (5, 8, 25%) [43].…”

Section: Bacterial Vaginosismentioning

confidence: 99%

Recent Advances in Nanosystems and Strategies for Vaginal Delivery of Antimicrobials

et al. 2021

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Vaginal infections such as bacterial vaginosis (BV), chlamydia, gonorrhea, genital herpes, candidiasis, and trichomoniasis affect millions of women each year. They are caused by an overgrowth of microorganisms, generally sexually transmitted, which in turn can be favored by alterations in the vaginal flora. Conventional treatments of these infections consist in systemic or local antimicrobial therapies. However, in the attempt to reduce adverse effects and to contrast microbial resistance and infection recurrences, many efforts have been devoted to the development of vaginal systems for the local delivery of antimicrobials. Several topical dosage forms such as aerosols, lotions, suppositories, tablets, gels, and creams have been proposed, although they are sometimes ineffective due to their poor penetration and rapid removal from the vaginal canal. For these reasons, the development of innovative drug delivery systems, able to remain in situ and release active agents for a prolonged period, is becoming more and more important. Among all, nanosystems such as liposomes, nanoparticles (NPs), and micelles with tunable surface properties, but also thermogelling nanocomposites, could be exploited to improve local drug delivery, biodistribution, retention, and uptake in vulvovaginal tissues. The aim of this review is to provide a survey of the variety of nanoplatforms developed for the vaginal delivery of antimicrobial agents. A concise summary of the most common vaginal infections and of the conventional therapies is also provided.

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“…Models that exist largely focus on cilial beating ( Smith et al, 2008 ; Norton et al, 2011 ) or individual pores of the mucus layer ( Cu and Saltzman, 2009 ; Hansing and Netz, 2018a , b ). Other models are simplified to the point of ignoring fluid movement or the existence of multiple fluid layers ( Kirch et al, 2012 ; Sims et al, 2019 )–both of which leave questions about locating dosage sites or macroscopic behavior unanswered. The purpose of this research is to help fill that gap by producing a model that simulates the lung airway mucosal layers ( Fig.…”

Section: Introductionmentioning

confidence: 99%

Computational fluid dynamics modeling of aerosol particle transport through lung airway mucosa

Bartlett,

Feng,

Fromen

et al. 2023

Computers & Chemical Engineering

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Modeling of nanoparticle transport through the female reproductive tract for the treatment of infectious diseases

Cited by 6 publications

References 54 publications

Recent advances in the mucus-interacting approach for vaginal drug delivery: from mucoadhesive to mucus-penetrating nanoparticles

Recent advances in the mucus-interacting approach for vaginal drug delivery: from mucoadhesive to mucus-penetrating nanoparticles

Recent Advances in Nanosystems and Strategies for Vaginal Delivery of Antimicrobials

Computational fluid dynamics modeling of aerosol particle transport through lung airway mucosa

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