volume 4, issue 11, P803-822 2012
DOI: 10.18632/aging.100503
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Abstract: AIMSWe identified an autosomal dominant non-sense mutation (R225X) in exon 4 of the lamin A/C (LMNA) gene in a Chinese family spanning 3 generations with familial dilated cardiomyopathy (DCM). In present study, we aim to generate induced pluripotent stem cells derived cardiomyocytes (iPSC-CMs) from an affected patient with R225X and another patient bearing LMNA frame-shift mutation for drug screening.METHODS and RESULTSHigher prevalence of nuclear bleb formation and micronucleation was present in LMNAR225X/WT …

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