volume 8, issue 1-2, P17-24 2000
DOI: 10.1016/s0928-4869(00)00003-3
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Jani Pusenjak, Damijan Miklavcic

Abstract: Interstitial¯uid pressure (IFP) is one of the main obstacles for macromolecular agents uptake and distribution in solid tumors. It has been demonstrated to reduce eectiveness of different macromolecular agents used in in vivo anti-tumor therapies, which on the other hand showed very good anti-tumor properties in in vitro conditions [L.T. Baxter, R.K. Jain, Microvascular Research 37 (1989) 77±104]. With an appropriate model we demonstrated the correlation between dierent physiological properties of solid tumor …

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