2016
DOI: 10.1016/j.maturitas.2016.01.015
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Abstract: The human menopause transition and aging are each associated with an increase in a variety of health risk factors including, but not limited to, cardiovascular disease, osteoporosis, cancer, diabetes, stroke, sexual dysfunction, affective disorders, sleep disturbances, and cognitive decline. It is often challenging to systematically evaluate the biological underpinnings associated with the menopause transition in the human population. For this reason, rodent models have been invaluable tools for studying the i… Show more

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Cited by 182 publications
(126 citation statements)
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References 132 publications
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“…In humans, postmenopausal women begin to have increased visceral fat accrual (Camhi et al 2011). Therefore, potential differences in visceral adipose tissue in our model might only be seen at oestropause, which in rodents is at 9-12 months of age (Koebele & Bimonte-Nelson, 2016). In addition to the physical differences found between offspring of LP-and C-fed mothers, we found maternal glucose intolerance when LPP females were subjected to an IPGTT at GD18.…”
Section: Discussionmentioning
confidence: 87%
See 1 more Smart Citation
“…In humans, postmenopausal women begin to have increased visceral fat accrual (Camhi et al 2011). Therefore, potential differences in visceral adipose tissue in our model might only be seen at oestropause, which in rodents is at 9-12 months of age (Koebele & Bimonte-Nelson, 2016). In addition to the physical differences found between offspring of LP-and C-fed mothers, we found maternal glucose intolerance when LPP females were subjected to an IPGTT at GD18.…”
Section: Discussionmentioning
confidence: 87%
“…). Therefore, potential differences in visceral adipose tissue in our model might only be seen at oestropause, which in rodents is at 9–12 months of age (Koebele & Bimonte‐Nelson, ).…”
Section: Discussionmentioning
confidence: 97%
“…Some research shows that women who experience surgical menopause prior to natural, transitional menopause onset have poorer verbal memory scores and may have a greater risk for developing cognitive impairments, as well as dementia, later in life (Nappi et al, 1999; Rocca et al, 2007). Our laboratory recently extended these findings using the 4-vinylcyclohexene diepoxide transitional menopause rodent model, which acts by chemically inducing ovarian follicular depletion to produce an ovarian and hormone profile similar to women undergoing the transition to menopause (Koebele and Bimonte-Nelson, 2016). We found that animals that underwent the transition to menopause in young adulthood exhibited working memory impairments compared to normally aging adult rats, whereas transitionally menopausal middle-aged rats performed similarly to middle-aged control rats.…”
Section: On the Role Of Midlife Changes In Ovarian Hormones Gonadmentioning
confidence: 92%
“…Rather, the driving mechanism underlying reproductive senescence in rodents is a significant dysregulation of the hypothalamic-pituitary-gonadal (HPG) axis in middle age (for review, see Downs and Wise, 2009; Finch, 2014; Wise, 2002; Wise et al, 1989, 1996, 1997, 1999). Thus, the introduction of 4-vinylcyclohexene diepoxide (VCD) as a rodent model of transitional menopause has given researchers another tool to model menopause in the preclinical laboratory (for review, see Koebele and Bimonte-Nelson, 2016). VCD targets primordial and primary ovarian follicles by initiating accelerated atresia, or programmed cell death, in the ovary (Hoyer et al, 2001; Springer et al, 1996c), resulting in follicular depletion and eventual ovarian failure in rodents (Borman et al, 1999; Flaws et al, 1994; Hirshfield, 1991; Hoyer et al, 2001; Hu et al, 2001a, 2001b; Kao et al, 1999; Mayer et al, 2002, 2004, 2005; Springer et al, 1996a, 1996b, 1996c).…”
Section: Introductionmentioning
confidence: 99%