2018
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Abstract: Separation of enantiomers is a major concern in pharmaceutical industries due to the different therapeutic activities exhibited by the enantiomers. Preferential crystallization is an attractive means to separate the conglomerate-forming enantiomers. In this work, a simulation study is presented for a proposed novel preferential crystallization configuration that involves coupled plug flow crystallizers (PFCs). The PFCs are coupled through liquid phase exchange which helps the enrichment of the preferred enanti… Show more

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Cited by 9 publications
(5 citation statements)
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References 44 publications
(64 reference statements)
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“…Several groups have studied the behaviour of the process of temperature-cycling-induced deracemization, either experimentally or computationally via the use of population balance equations. While earlier experimental studies relied on simple first-order kinetics expressions to describe the progress and the time-evolution of the enantiomeric excess [8], later more detailed models using population balance equations have been developed [10][11][12][13]. In the context of this work, we were looking for a simple way to quantify the efficiency of the deracemization process depending on the process settings of individual trials and relate it to the number of cycles performed.…”
Section: Evaluation Of Resultsmentioning
confidence: 99%
“…Several groups have studied the behaviour of the process of temperature-cycling-induced deracemization, either experimentally or computationally via the use of population balance equations. While earlier experimental studies relied on simple first-order kinetics expressions to describe the progress and the time-evolution of the enantiomeric excess [8], later more detailed models using population balance equations have been developed [10][11][12][13]. In the context of this work, we were looking for a simple way to quantify the efficiency of the deracemization process depending on the process settings of individual trials and relate it to the number of cycles performed.…”
Section: Evaluation Of Resultsmentioning
confidence: 99%
“…7). 91 Recently, Cameli et al 54 reported the continuous preferential crystallization of isoindoline-1-ones derivatives using a plug flow crystallizer immersed in two thermostatic baths set at different temperatures. This configuration allowed them to obtain productivities of 20 g L −1 h −1 due to the excellent heat transfer and low residence periods (Table 4 and Fig.…”
Section: Preferential Crystallizationmentioning
confidence: 99%
“…This Special Issue contains five contributions covering applications of PBM in a wide range of applications ranging from crystallization, granulation and flotation to social aspects. Majumder [1] discussed the preferential crystallization as a promising separation technology for conglomerate-forming enantiomers, which is a challenge in pharmaceutical manufacturing to develop different therapeutics. In his study, a simulation was carried out coupled with a set of population balance equations to describe the evolution of the crystal size distribution.…”
Section: Applicationsmentioning
confidence: 99%