Model-Free Adaptive Fault-Tolerant Control for Multiple Point-Mass Subway Trains With Speed and Traction/Braking Force Constraints

Wang, Haojun; Hou, Zhongsheng; Jin, Shangtai

doi:10.1016/j.ifacol.2020.12.2239

Cited by 6 publications

(3 citation statements)

References 21 publications

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“…15 Other protein engineering studies of BVMOs have been reviewed. 16 Whereas the primary focus was on stereoselectivity, efforts aimed at improving or reversing regioselectivity (sometimes called site-selectivity) 17 have increased recently. A seminal example concerns the switch from abnormal to normal product in the BV reaction of (+)-trans-dihydrocarvone catalyzed by an evolved CHMO mutant from Arthrobacter sp.…”

Section: ■ Introductionmentioning

confidence: 99%

Overriding Traditional Electronic Effects in Biocatalytic Baeyer–Villiger Reactions by Directed Evolution

Garcia‐Borràs

Fürst

et al. 2018

J. Am. Chem. Soc.

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Controlling the regioselectivity of Baeyer-Villiger (BV) reactions remains an ongoing issue in organic chemistry, be it by synthetic catalysts or enzymes of the type Baeyer-Villiger monooxygenases (BVMOs). Herein, we address the challenging problem of switching normal to abnormal BVMO regioselectivity by directed evolution using three linear ketones as substrates, which are not structurally biased toward abnormal reactivity. Upon applying iterative saturation mutagenesis at sites lining the binding pocket of the thermostable BVMO from Thermocrispum municipale DSM 44069 (TmCHMO) and using 4-phenyl-2-butanone as substrate, the regioselectivity was reversed from 99:1 (wild-type enzyme in favor of the normal product undergoing 2-phenylethyl migration) to 2:98 in favor of methyl migration when applying the best mutant. This also stands in stark contrast to the respective reaction using the synthetic reagent m-CPBA, which provides solely the normal product. Reversal of regioselectivity was also achieved in the BV reaction of two other linear ketones. Kinetic parameters and melting temperatures revealed that most of the evolved mutants retained catalytic activity, as well as thermostability. In order to shed light on the origin of switched regioselectivity in reactions of 4-phenyl-2-butanone and phenylacetone, extensive QM/MM and MD simulations were performed. It was found that the mutations introduced by directed evolution induce crucial changes in the conformation of the respective Criegee intermediates and transition states in the binding pocket of the enzyme. In mutants that destabilize the normally preferred migration transition state, a reversal of regioselectivity is observed. This conformational control of regioselectivity overrides electronic control, which normally causes preferential migration of the group that is best able to stabilize positive charge. The results can be expected to aid future protein engineering of BVMOs.

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Section: ■ Introductionmentioning

confidence: 99%

Overriding Traditional Electronic Effects in Biocatalytic Baeyer–Villiger Reactions by Directed Evolution

Garcia‐Borràs

Fürst

et al. 2018

J. Am. Chem. Soc.

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“…The authors 29 used the MFAC method to solve the subway trains considering actuator fault‐tolerant control. Further, the authors study the fault‐tolerant control problem of multi‐point mass train system 30 …”

Section: Introductionmentioning

confidence: 99%

“…Further, the authors study the fault-tolerant control problem of multi-point mass train system. 30 Some studies have been done to solve the complex subway train system only by using TB-S data, but the problem of network attacks has not been considered. However, in the practical application, DoS attacks are still easy to occur in the network.…”

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confidence: 99%

Dynamic event‐triggered model‐free adaptive security tracking control for constrained subway train system

Zhu

Che

2022

Intl J Robust & Nonlinear

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In this article, the dynamic event-triggered model-free adaptive security tracking control problem of the subway system with speed and traction/braking force constraints under aperiodic denial-of-service (DoS) attacks is studied. The complex subway train system is transformed into a linearization data model by using the dynamic linearization technique. For the subway system, both speed and traction/braking forces need to be restrained to ensure the safety of the subway equipment. In addition, the dynamic event-triggered mechanism is designed to reduce communication frequency and prolong the hardware life cycle. At the same time, considering aperiodic DoS attacks in the network channel, the security tracking control problem is guaranteed. In the simulation, the algorithm is applied to the subway train system, and the effectiveness of this algorithm is verified with a comparison. K E Y W O R D Saperiodic DoS attacks, constrained subway train system, dynamic event-triggered mechanism, model-free adaptive control INTRODUCTIONWith the emergence of technologies in the field of the network, such as the big data processing technology and the cloud computing technology, it further promotes the development of cyber-physical systems (CPSs). 1,2 The system uses the unlimited data and information resources of the network system to break through the limitations of the physical resources. The intelligent transportation system is one kind of CPSs, 3 among which subway train system has been widely concerned.Compared with the ordinary train, the subway train control may have a series of new challenges, such as network attacks and excessive data transmissions. Attacks on the network may affect the stability of the train operation and even endanger passengers safety. A large amount of data will be generated during the train operation, which leads to extremely high calculation costs. All of the above issues need to be thoroughly studied and discussed.Considering that data generated by trains may encounter many problems when transmitted over network channels, such as attacks, packet loss and so on. [4][5][6] Although there are so many problems with the transmission over the network, one of the problems that affect the system most is the network attack. There are two main types of attacks: denial-of-service (DoS) attacks and false data injection (FDI) attacks. 7,8 Research on DoS attacks has been studied for many years. 9-16 DoS attacks are usually handled in three ways: detection attacks, resistance attacks, and compensation attacks. A model was designed to evaluate the effect of DoS attacks, 9 which can not only evaluate individual attacks, but also can rank the effects of attacks. An active security attack strategy for the two-channel attacks was designed by taking full advantage of Abbreviations: DET-MFASTC, dynamic event-triggered model-free adaptive security tracking control; DoS, denial-of-service; PPD, pseudo-partial derivative.

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Model-Free Adaptive Fault-Tolerant Control for Offshore Wind Turbines

Lam,

Simani

2024

Lecture Notes in Networks and Systems

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Model-Free Adaptive Fault-Tolerant Control for Multiple Point-Mass Subway Trains With Speed and Traction/Braking Force Constraints

Cited by 6 publications

References 21 publications

Overriding Traditional Electronic Effects in Biocatalytic Baeyer–Villiger Reactions by Directed Evolution

Overriding Traditional Electronic Effects in Biocatalytic Baeyer–Villiger Reactions by Directed Evolution

Dynamic event‐triggered model‐free adaptive security tracking control for constrained subway train system

Model-Free Adaptive Fault-Tolerant Control for Offshore Wind Turbines

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