A first-rate e-Health system saves lives, provides better patient care, allows complex but useful epidemiologic analysis and saves money. However, there may also be concerns about the costs and complexities associated with e-health implementation, and the need to solve issues about the energy footprint of the high-demanding computing facilities. This paper proposes a novel and evolved computing paradigm that: i) provides the required computing and sensing resources; ii) allows the population-wide diffusion; iii) exploits the storage, communication and computing services provided by the Cloud; iv) tackles the energy-optimization issue as a first-class requirement, taking it into account during the whole development cycle. The novel computing concept, and the multilayer top-down energy-optimization methodology, obtain promising results in a realistic scenario for cardiovascular tracking and analysis, making the Home Assisted Living a reality.