Mobilization of lead in mice by administration of monoalkyl esters of meso-2,3-dimercaptosuccinic acid

Therapeutic potential of monoisoamyl and monomethyl esters of meso 2,3-dimercaptosuccinic acid in gallium arsenide intoxicated rats

“…Kostial et al (1995) reported that monoisoamyl DMSA and mono-n-hexyl DMSA (MnHDMSA) are superior to DMSA in mobilizing mercury from body and organs. The same monoesters were also found to be efficient in decreasing body lead burden of mice (Walker et al, 1992). Gale et al (1993) evaluated the mercury level in mice after oral treatment with seven DMSA monoesters at a dose of 2 × 0.5 mmol kg −1 and found them to be superior to DMSA and DMPS.…”

Therapeutic potential of monoisoamyl and monomethyl esters of meso 2,3-dimercaptosuccinic acid in gallium arsenide intoxicated rats

“…Kostial et al (1995) reported that monoisoamyl DMSA and mono-n-hexyl DMSA (MnHDMSA) are superior to DMSA in mobilizing mercury from body and organs. The same monoesters were also found to be efficient in decreasing body lead burden of mice (Walker et al, 1992). Gale et al (1993) evaluated the mercury level in mice after oral treatment with seven DMSA monoesters at a dose of 2 × 0.5 mmol kg −1 and found them to be superior to DMSA and DMPS.…”

Haematological, hepatic and renal alterations after repeated oral and intraperitoneal administration of monoisoamyl DMSA. II. Changes in female rats

“…We thus thought it necessary to observe the effects in male and female rats separately. We believe that the data will be useful for metal toxicologists working on this compound for its therapeutic efficacy against mercury (Gale et al, 1993), cadmium , lead (Walker et al, 1992) and arsenic . Although, the ld 50 value for the compound was reported earlier to be 3.0 mmol kg −1 , we selected three doses that were found to be effective against arsenic and lead poisoning Pande and Flora, 2002).…”

Changes in brain biogenic amines and haem biosynthesis and their response to combined administration of succimers and Centella asiatica in lead poisoned rats

“…MiADMSA is among the series of newly synthesized monoesters of DMSA found to be highly effective against cadmium and mercury poisoning Kostial et al 1995). Walker et al (1992) and Saxena et al (2005) also reported superior efficacy of monoesters to DMSA in mobilizing brain lead. The greater effectiveness of MiADMSA compared with DMSA in mobilizing lead from the body and reducing its toxic effects may be attributed to its ability to gain intracellular access to various endogenous ligands (i.e., its lipophilic nature) ( Figure 4).…”

Therapeutic potential of monoisoamyl and monomethyl esters of meso 2,3-dimercaptosuccinic acid in gallium arsenide intoxicated rats

“…Kostial et al (1995) reported that monoisoamyl DMSA and mono-n-hexyl DMSA (MnHDMSA) are superior to DMSA in mobilizing mercury from body and organs. The same monoesters were also found to be efficient in decreasing body lead burden of mice (Walker et al, 1992). Gale et al (1993) evaluated the mercury level in mice after oral treatment with seven DMSA monoesters at a dose of 2 × 0.5 mmol kg −1 and found them to be superior to DMSA and DMPS.…”

Haematological, hepatic and renal alterations after repeated oral and intraperitoneal administration of monoisoamyl DMSA. II. Changes in female rats

“…We thus thought it necessary to observe the effects in male and female rats separately. We believe that the data will be useful for metal toxicologists working on this compound for its therapeutic efficacy against mercury (Gale et al, 1993), cadmium , lead (Walker et al, 1992) and arsenic . Although, the ld 50 value for the compound was reported earlier to be 3.0 mmol kg −1 , we selected three doses that were found to be effective against arsenic and lead poisoning Pande and Flora, 2002).…”

Changes in brain biogenic amines and haem biosynthesis and their response to combined administration of succimers and Centella asiatica in lead poisoned rats

“…MiADMSA is among the series of newly synthesized monoesters of DMSA found to be highly effective against cadmium and mercury poisoning Kostial et al 1995). Walker et al (1992) and Saxena et al (2005) also reported superior efficacy of monoesters to DMSA in mobilizing brain lead. The greater effectiveness of MiADMSA compared with DMSA in mobilizing lead from the body and reducing its toxic effects may be attributed to its ability to gain intracellular access to various endogenous ligands (i.e., its lipophilic nature) ( Figure 4).…”

Therapeutic potential of monoisoamyl and monomethyl esters of meso 2,3-dimercaptosuccinic acid in gallium arsenide intoxicated rats

“…Kostial et al (1995) reported that monoisoamyl DMSA and mono-n-hexyl DMSA (MnHDMSA) are superior to DMSA in mobilizing mercury from body and organs. The same monoesters were also found to be efficient in decreasing body lead burden of mice (Walker et al, 1992). Gale et al (1993) evaluated the mercury level in mice after oral treatment with seven DMSA monoesters at a dose of 2 × 0.5 mmol kg −1 and found them to be superior to DMSA and DMPS.…”

Haematological, hepatic and renal alterations after repeated oral and intraperitoneal administration of monoisoamyl DMSA. II. Changes in female rats

“…We thus thought it necessary to observe the effects in male and female rats separately. We believe that the data will be useful for metal toxicologists working on this compound for its therapeutic efficacy against mercury (Gale et al, 1993), cadmium , lead (Walker et al, 1992) and arsenic . Although, the ld 50 value for the compound was reported earlier to be 3.0 mmol kg −1 , we selected three doses that were found to be effective against arsenic and lead poisoning Pande and Flora, 2002).…”

Changes in brain biogenic amines and haem biosynthesis and their response to combined administration of succimers and Centella asiatica in lead poisoned rats

“…MiADMSA is among the series of newly synthesized monoesters of DMSA found to be highly effective against cadmium and mercury poisoning Kostial et al 1995). Walker et al (1992) and Saxena et al (2005) also reported superior efficacy of monoesters to DMSA in mobilizing brain lead. The greater effectiveness of MiADMSA compared with DMSA in mobilizing lead from the body and reducing its toxic effects may be attributed to its ability to gain intracellular access to various endogenous ligands (i.e., its lipophilic nature) ( Figure 4).…”