2010
DOI: 10.1007/s00018-010-0389-4
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Abstract: Bacteria such as Staphylococcus aureus are successful as commensal organisms or pathogens in part because they adapt rapidly to selective pressures imparted by the human host. Mobile genetic elements (MGEs) play a central role in this adaptation process and are a means to transfer genetic information (DNA) among and within bacterial species. Importantly, MGEs encode putative virulence factors and molecules that confer resistance to antibiotics, including the gene that confers resistance to beta-lactam antibiot… Show more

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Cited by 418 publications
(359 citation statements)
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References 169 publications
(147 reference statements)
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“…Some authors reported a predominant and systematic co-detection of seg and sei genes (Rosec and Gigaud 2002) whereas others have reported their presence individually or in different combinations with other se genes (Arcuri et al 2010;Cremonesi et al 2007;Zouharova and Rysanek 2008). The association between seg and sei has been attributed to their location within the same gene cluster (egc) in the genomic island mSAb (also known as SaPIn3/m3) (Malachowa and DeLeo 2010). In our study, one isolate harboring only the seg gene was found.…”
Section: Detection Of Se and Tst Genesmentioning
confidence: 40%
“…Some authors reported a predominant and systematic co-detection of seg and sei genes (Rosec and Gigaud 2002) whereas others have reported their presence individually or in different combinations with other se genes (Arcuri et al 2010;Cremonesi et al 2007;Zouharova and Rysanek 2008). The association between seg and sei has been attributed to their location within the same gene cluster (egc) in the genomic island mSAb (also known as SaPIn3/m3) (Malachowa and DeLeo 2010). In our study, one isolate harboring only the seg gene was found.…”
Section: Detection Of Se and Tst Genesmentioning
confidence: 40%
“…The differences in phage patterns in these studies could be, in part, due to different geographical locations where these studies were performed. The double lysogenic (SGB and SGF) and the two subtypes (SGFa and SGFb) of prophages have shown to be associated with production of a broad spectrum of virulence factors (4,19). In the current study the ability of the isolates to produce these virulence factors were not investigated, and therefore the pathogenic properties of the isolates associated with this unique pattern can not be fully confirmed.…”
Section: Discussionmentioning
confidence: 84%
“…It has been estimated that some 20% of the extant genetic content of any given bacterial species has been acquired from other organisms by means of mobile genetic elements (MGE) such as bacteriophages, insertion sequences (IS), plasmids, and transposons (3)(4)(5).…”
Section: Introductionmentioning
confidence: 99%
“…(8,9) Resistance to methicillin in S. aureus strains is due to expression of an altered penicillin-binding protein (PBP2a) with low affinity for β-lactam antibiotics, encoded by mecA gene. (10,11) The mecA gene is a part of 21 up to 67 bp genetic mobile elements called Staphylococcal Cassette Chromosome (SCC) with different size and genetic composition among Methicillin-Resistant S. aureus (MRSA) strains. (12) Currently various SCCmec elements have been identified and classified into different types such as I, II, III, IV, V, VI and etc.…”
Section: Introductionmentioning
confidence: 99%