MMSET is overexpressed in cancers: Link with tumor aggressiveness

Kassambara, Alboukadel; Klein, Bernard; Moreaux, Jérôme

doi:10.1016/j.bbrc.2008.12.093

Cited by 74 publications

(67 citation statements)

References 56 publications

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“…Robust expression of ACA11 was significantly associated with the t(4;14) translocation in MM cell lines and patient samples (Figure 1, D-F). ACA11 was also overexpressed in a subset of samples from patients with primary colon, esophageal, and bladder cancer (Figure 2), consistent with its location within WHSC1 (16). These data confirm ACA11 overexpression in t(4;14)-positive MM, but additional studies are required to confirm the hypothesis that ACA11 is upregulated in other cancer types.…”

Section: Whsc1 Cdnas Are Not Sufficient To Induce Malignant Transformsupporting

confidence: 69%

“…First, WHSC1 transcripts are consistently overexpressed in t(4;14)-positive myelomas, and WHSC1 is also upregulated by unknown mechanisms in subsets of diverse solid tumor types, including neuroblastoma, in which high WHSC1 levels are associated with tumor aggressiveness (14)(15)(16). Second, transcriptional deregulation by the HMT encoded by WHSC1 is a plausible mechanism of carcinogenesis.…”

Section: Introductionmentioning

confidence: 99%

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Multiple myeloma–associated chromosomal translocation activates orphan snoRNA ACA11 to suppress oxidative stress

Chu

Su²,

Maggi³

et al. 2012

J. Clin. Invest.

135

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Section: Whsc1 Cdnas Are Not Sufficient To Induce Malignant Transformsupporting

confidence: 69%

Section: Introductionmentioning

confidence: 99%

Multiple myeloma–associated chromosomal translocation activates orphan snoRNA ACA11 to suppress oxidative stress

Chu

Su²,

Maggi³

et al. 2012

J. Clin. Invest.

135

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“…All data were log transformed, median centered per array, and the standard deviation was normalized to one per array [11].…”

Section: Methodsmentioning

confidence: 99%

STEAP1 is overexpressed in cancers: A promising therapeutic target

Moreaux

Kassambara

Hose

et al. 2012

Biochemical and Biophysical Research Communications

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The six-transmembrane epithelial antigen of prostate (STEAP) protein was identified in advanced prostate cancer and is up-regulated in multiple cancer cell lines, including prostate, bladder, colon, ovarian, and Ewing sarcoma. STEAP1 was described as a suitable antigen for T-cell-based or antibody-based immunotherapy.We have investigated the expression of STEAP1 in 40 human tumor types -brain, epithelial, lymphoid -and in their normal tissue counterparts using publicly available gene expression data, including the Oncomine Cancer Microarray database. STEAP1 was found significantly overexpressed in 11 cancers. In addition, high STEAP1 expression was associated with poor overall survival in colorectal cancer, diffuse large B cell lymphoma, acute myeloid leukemia and multiple myeloma.Taken together, these data suggest that STEAP1 is a potential therapeutic target for Tcell based immunotherapy or antibody therapy in a large panel of cancers.3

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“…The amplification of either NSD1 or NSD2 triggers cellular transformation [21][22][23][24][25][26][27][28]. NSD2 is associated with tumor aggressiveness or prognosis in most types of cancers, including prostate cancer and multiple myeloma and is overexpressed in at least 15 different cancers [9,10,17,18,20,21,25,[29][30][31][32][33]. Increased NSD2 activity is also reported during tumor proliferation in glioblastoma and myeloma [34], resulting in aberrantly high global levels of H3K36me2 [18].…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, the inhibition of NSD members by small molecules represents a valuable therapeutic strategy in several human cancers where elevated levels of NSD members have been reported [2,4,5,12,14,17,18,26,32,33,[43][44][45].…”

Section: Introductionmentioning

confidence: 99%

In vitro histone lysine methylation by NSD1, NSD2/MMSET/WHSC1, and NSD3/WHSC1L

Morishita

Mevius

Luccio

2014

BMC Structural Biology

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Background: Histone lysine methylation has a pivotal role in regulating the chromatin. Histone modifiers, including histone methyl transferases (HMTases), have clear roles in human carcinogenesis but the extent of their functions and regulation are not well understood. The NSD family of HMTases comprised of three members (NSD1, NSD2/ MMSET/WHSC1, and NSD3/WHSC1L) are oncogenes aberrantly expressed in several cancers, suggesting their potential to serve as novel therapeutic targets. However, the substrate specificity of the NSDs and the molecular mechanism of histones H3 and H4 recognition and methylation have not yet been established.

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MMSET is overexpressed in cancers: Link with tumor aggressiveness

Cited by 74 publications

References 56 publications

Multiple myeloma–associated chromosomal translocation activates orphan snoRNA ACA11 to suppress oxidative stress

Multiple myeloma–associated chromosomal translocation activates orphan snoRNA ACA11 to suppress oxidative stress

STEAP1 is overexpressed in cancers: A promising therapeutic target

In vitro histone lysine methylation by NSD1, NSD2/MMSET/WHSC1, and NSD3/WHSC1L

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