MMPs, ADAMs and ADAMTSs are associated with mammalian sperm fate

Li, Yunxiang; Chen, Yuguang; Wu, Weimin; Li, Na; Hua, Jinlian

doi:10.1016/j.theriogenology.2023.02.013

Cited by 6 publications

(2 citation statements)

References 72 publications

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“…The testis is a highly complex gland comprising Leydig, Sertoli, germ, and peritubular myoid cells, as well as extracellular matrix (ECM) material ( Li et al, 2023 ). Interactions among these cells are crucial for correct ECM remodeling, as well as several developmental and morphogenetic processes ( Piprek et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Cascading effects of hypobaric hypoxia on the testis: insights from a single-cell RNA sequencing analysis

Ji,

Wang,

Zhang

et al. 2023

Front. Cell Dev. Biol.

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Most mammals tolerate exposure to hypobaric hypoxia poorly as it may affect multiple regulatory mechanisms and inhibit cell proliferation, promote apoptosis, limit tissue vascularization, and disrupt the acid–base equilibrium. Here, we quantified the functional state of germ cell development and demonstrated the interaction between the germ and somatic cells via single-cell RNA sequencing (scRNA-seq). The present study elucidated the regulatory effects of hypobaric hypoxia exposure on germ cell formation and sperm differentiation by applying enrichment analysis to genomic regions. Hypobaric hypoxia downregulates the genes controlling granule secretion and organic matter biosynthesis, upregulates tektin 1 (TEKT1) and kinesin family member 2C (KIF2C), and downregulates 60S ribosomal protein 11 (RPL11) and cilia- and flagella-associated protein 206 (CFAP206). Our research indicated that prosaposin-G protein-coupled receptor 37 (PSAP-GPR37) ligands mediate the damage to supporting cells caused by hypobaric hypoxic exposure. The present work revealed that hypoxia injures peritubular myoid (PTM) cells and spermatocytes in the S phase. It also showed that elongating spermatids promote maturation toward the G2 phase and increase their functional reserve for sperm–egg binding. The results of this study provide a theoretical basis for future investigations on prophylactic and therapeutic approaches toward protecting the reproductive system against the harmful effects of hypobaric hypoxic exposure.

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Section: Discussionmentioning

confidence: 99%

Cascading effects of hypobaric hypoxia on the testis: insights from a single-cell RNA sequencing analysis

Ji,

Wang,

Zhang

et al. 2023

Front. Cell Dev. Biol.

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show abstract

“…Previously, we identified several genes involved in immune regulatory pathways that may be significantly affected by NHS exposure, and thus may contribute to the immunological barrier created by NPSC 4 . In addition to immunity, four of the DEG are related to cellular adhesion and may influence the BTB to affect germ cell viability 4 , 7–10 . These genes include E-selectin (SELE), a disintegrin and metalloprotease 7 (ADAM7), vascular cellular adhesion molecule 1 (VCAM1), and vascular endothelial growth factor A (VEGFA).…”

Section: Perspectivementioning

confidence: 99%

Regulation of complement by Sertoli cells may contribute to the immune protective environment within the blood-testis barrier

Washburn

Dufour

2023

Tissue Barriers

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Sertoli cells are a crucial component of the blood-testis barrier (BTB), which isolates the adluminal compartment of the seminiferous tubules from the rest of the testis thus forming an environment to immunely protect the developing germ cells. The mechanisms of regulating immune responses within this environment are currently under investigation. Here, we focused on Sertoli cell regulation of the complement system.

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A novel role of ADAMTS16 in renal fibrosis through activating TGF-β/Smad signaling

Zhao,

Tian,

Huang

et al. 2024

Cellular Signalling

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MMPs, ADAMs and ADAMTSs are associated with mammalian sperm fate

Cited by 6 publications

References 72 publications

Cascading effects of hypobaric hypoxia on the testis: insights from a single-cell RNA sequencing analysis

Cascading effects of hypobaric hypoxia on the testis: insights from a single-cell RNA sequencing analysis

Regulation of complement by Sertoli cells may contribute to the immune protective environment within the blood-testis barrier

A novel role of ADAMTS16 in renal fibrosis through activating TGF-β/Smad signaling

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