MMP14 is required for delamination of chick neural crest cells independently of its catalytic activity

Andrieu, Cyril; Montigny, Audrey; Bibonne, Anne; Despin-Guitard, Evangéline; Alfandari, Dominique; Théveneau, Eric

doi:10.1242/dev.183954

Cited by 23 publications

(20 citation statements)

References 67 publications

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“…It is important to note that, in addition to proteolysis of ECM, MMPs have significant non-proteolytic functions that can alter tumour progression. For example, MMP-3 binds and inhibits noncanonical Wnt5b, resulting in increased canonical Wnt signalling 9 , and MT1-MMP promotes basal extrusion during epithelial-to-mesenchymal transition (EMT) and basal mitosis noncatalytically 118 .…”

Section: Glycosylation Fibronectin Glycosyltransferases and Glycosidasesmentioning

confidence: 99%

Concepts of extracellular matrix remodelling in tumour progression and metastasis

et al. 2020

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Tissues are dynamically shaped by bidirectional communication between resident cells and the extracellular matrix (ECM) through cell-matrix interactions and ECM remodelling. Tumours leverage ECM remodelling to create a microenvironment that promotes tumourigenesis and metastasis. In this review, we focus on how tumour and tumour-associated stromal cells deposit, biochemically and biophysically modify, and degrade tumour-associated ECM. These tumour-driven changes support tumour growth, increase migration of tumour cells, and remodel the ECM in distant organs to allow for metastatic progression. A better understanding of the underlying mechanisms of tumourigenic ECM remodelling is crucial for developing therapeutic treatments for patients.

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Section: Glycosylation Fibronectin Glycosyltransferases and Glycosidasesmentioning

confidence: 99%

Concepts of extracellular matrix remodelling in tumour progression and metastasis

et al. 2020

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“…Sectioning. After staining, embryos were prepared as described in Andrieu et al 64 www.nature.com/scientificreports/ embryos per condition from at least two independent experiments. Numbers of individuals (n) are indicated in figure legends.…”

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confidence: 99%

Sulf2a controls Shh-dependent neural fate specification in the developing spinal cord

Danesin

Darche-Gabinaud

Escalas

et al. 2021

Sci Rep

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Sulf2a belongs to the Sulf family of extracellular sulfatases which selectively remove 6-O-sulfate groups from heparan sulfates, a critical regulation level for their role in modulating the activity of signalling molecules. Data presented here define Sulf2a as a novel player in the control of Sonic Hedgehog (Shh)-mediated cell type specification during spinal cord development. We show that Sulf2a depletion in zebrafish results in overproduction of V3 interneurons at the expense of motor neurons and also impedes generation of oligodendrocyte precursor cells (OPCs), three cell types that depend on Shh for their generation. We provide evidence that Sulf2a, expressed in a spatially restricted progenitor domain, acts by maintaining the correct patterning and specification of ventral progenitors. More specifically, Sulf2a prevents Olig2 progenitors to activate high-threshold Shh response and, thereby, to adopt a V3 interneuron fate, thus ensuring proper production of motor neurons and OPCs. We propose a model in which Sulf2a reduces Shh signalling levels in responding cells by decreasing their sensitivity to the morphogen factor. More generally, our work, revealing that, in contrast to its paralog Sulf1, Sulf2a regulates neural fate specification in Shh target cells, provides direct evidence of non-redundant functions of Sulfs in the developing spinal cord.

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“…Global inhibition of MMPs phenocopied the MEP glial phenotype we observed in foxd3 -/- larvae and this led us to hypothesize that foxd3 controls MEP glial exit through the regulation of MMP expression. MMPs are known to play a role in NCC migration in zebrafish and chick ( Andrieu et al, 2020 ; Leigh et al, 2013 ). Therefore, we asked whether expression of MMPs was perturbed in the ventral neural tube of foxd3 mutant embryos.…”

Section: Resultsmentioning

confidence: 99%

Spinal cord precursors utilize neural crest cell mechanisms to generate hybrid peripheral myelinating glia

Fontenas

Kucenas

2021

eLife

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During development, oligodendrocytes and Schwann cells myelinate central and peripheral nervous system axons, respectively, while motor exit point (MEP) glia are neural tube-derived, peripheral glia that myelinate axonal territory between these populations at MEP transition zones. From which specific neural tube precursors MEP glia are specified, and how they exit the neural tube to migrate onto peripheral motor axons, remain largely unknown. Here, using zebrafish, we found that MEP glia arise from lateral floor plate precursors and require foxd3 to delaminate and exit the spinal cord. Additionally, we show that similar to Schwann cells, MEP glial development depends on axonally-derived neuregulin1. Finally, our data demonstrate that overexpressing axonal cues is sufficient to generate additional MEP glia in the spinal cord. Overall, these studies provide new insight into how a novel population of hybrid, peripheral myelinating glia are generated from neural tube precursors and migrate into the periphery.

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MMP14 is required for delamination of chick neural crest cells independently of its catalytic activity

Cited by 23 publications

References 67 publications

Concepts of extracellular matrix remodelling in tumour progression and metastasis

Concepts of extracellular matrix remodelling in tumour progression and metastasis

Sulf2a controls Shh-dependent neural fate specification in the developing spinal cord

Spinal cord precursors utilize neural crest cell mechanisms to generate hybrid peripheral myelinating glia

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