MMP-2 and TIMP-2 in Cutaneous Melanoma: Association With Prognostic Factors and Description in Cutaneous Metastases

Next generation oncolytic viruses expressing PADI1 and TIMP2 exhibit anti-tumor activity against melanoma in nude and humanized mouse models

“…Both arginine deprivation which can be induced by PADI1 and TIMP2 which modulates MMP activity and thus ECM integrity are associated with regression. 48 Arginine deprivation exhibits anti-tumor activity against melanoma. 10 In this study, our four novel oncolytic adenoviruses armed to express one or both PADI1 and TIMP2 exhibited varied levels of cytotoxicity against four melanoma cell lines in vitro in a dose-dependent manner.…”

Thin cutaneous melanoma: immunohistochemical expression of endoglin, VEGF-C and nestin

“…The chromogenic substance was 3-Amino-9-Ethylcarbazole (AEC), as previously used in a prior study of melanoma. 4 …”

CD147 Is a Novel Chemotherapy or Prevention Target in Melanoma

“…MMP-2 and MMP-9, belonging to gelatinases, are the major proteases that digest IV collagen, a component of the basement membrane. It was reported that MMP-2 and MMP-9 expression and activity have been associated with melanoma metastasis and may represent a prognostic factor in melanoma (Berube et al, 2005;Cotignola et al, 2007;El-Shabrawi et al, 2001;Nischt et al, 2001;Rey et al, 2011;Tang et al, 2013).…”