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Tyazhelova, T. V.; Ivanov, Dmitry; Makeeva, Natalia; Kapanadze, Bagrat; Никитин, Е. А.; Semov, Alexandre; Sangfelt, Olle; Grandér, Dan; Vorobiev, A. I.; Einhorn, S.; Yankovsky, N. K.; Baranova, Ancha

doi:10.1023/a:1012561109880

Cited by 3 publications

(2 citation statements)

References 19 publications

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“…To identify the candidate for tumor suppressor genes for BCLL and prostate cancer locus at 13q14.3, an integrated genomic contig [8] and corresponding transcript map [9] were constructed. The new gene KCNRG was found via BLASTN search of the EST database of GenBank seeded with a genomic sequence (genbank:AF440619).…”

Section: Resultsmentioning

confidence: 99%

“…The indicated area is immersed in a wider region that is deleted in prostate cancer samples [6,7]. Four candidate genes belonging to this region, namely DLEU1 and DLEU2 [4], RFP2 [8], C13ORF1 [9] were cloned. All candidates have been extensively checked for mutations by SSCP analysis and have failed to detect small mutations in any of these genes ([4] and our unpublished data on C13ORF1 , and RFP2 ).…”

Section: Introductionmentioning

confidence: 99%

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A new human gene KCNRG encoding potassium channel regulating protein is a cancer suppressor gene candidate located in 13q14.3

et al. 2003

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We report the primary characterization of a new gene KCNRG mapped at chromosome band 13q14.3. This gene includes three exons and has two alternatively spliced isoforms that are expressed in normal tissues and in some tumor cell lines. Protein KCNRG has high homology to tetramerization domain of voltage-gated K + channels. Using the patchclamp technique we determined that KCNRG suppresses K + channel activity in human prostate cell line LNCaP. It is known that selective blockers of K + channels suppress lymphocyte and LNCaP cell line proliferation. We suggest that KCNRG is a candidate for a B-cell chronic lymphocytic leukemia and prostate cancer tumor suppressor gene. ß

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Section: Resultsmentioning

confidence: 99%