Mixtures of benomyl, pirimiphos-methyl, dimethoate, diazinon and azinphos-methyl affect protein synthesis in HL-60 cells differently

Dimethoate inhibits steroidogenesis by disrupting transcription of the steroidogenic acute regulatory (StAR) gene

“…In fact, as StAR is a cycloheximide-sensitive protein, a general reduction in protein synthesis could have explained the decrease in StAR protein levels and thus steroid production (Garren et al 1965). However, Dimethoate at concentrations as high as 100 µg/ml failed to affect total protein synthesis in MA-10 cells (this study) or in the human leukemia cell line, HL-60 (Marinovich et al 1994), indicating that it did not inhibit steroidogenesis by causing acute cellular toxicity or by inducing a general disruption in translation. These studies indicate that Dimethoate may have disrupted steroidogenesis by targeting specific sites within the cell.…”

Dimethoate inhibits steroidogenesis by disrupting transcription of the steroidogenic acute regulatory (StAR) gene

“…In fact, as StAR is a cycloheximide-sensitive protein, a general reduction in protein synthesis could have explained the decrease in StAR protein levels and thus steroid production (Garren et al 1965). However, Dimethoate at concentrations as high as 100 µg/ml failed to affect total protein synthesis in MA-10 cells (this study) or in the human leukemia cell line, HL-60 (Marinovich et al 1994), indicating that it did not inhibit steroidogenesis by causing acute cellular toxicity or by inducing a general disruption in translation. These studies indicate that Dimethoate may have disrupted steroidogenesis by targeting specific sites within the cell.…”

Evaluating Chemical Interaction Studies for Mixture Risk Assessment

“……”

Effect of coumaphos on cholinesterase activity, hematology, and biochemical blood parameters of bovines in tropical regions of Mexico

“……”

Dimethoate inhibits steroidogenesis by disrupting transcription of the steroidogenic acute regulatory (StAR) gene

“…In fact, as StAR is a cycloheximide-sensitive protein, a general reduction in protein synthesis could have explained the decrease in StAR protein levels and thus steroid production (Garren et al 1965). However, Dimethoate at concentrations as high as 100 µg/ml failed to affect total protein synthesis in MA-10 cells (this study) or in the human leukemia cell line, HL-60 (Marinovich et al 1994), indicating that it did not inhibit steroidogenesis by causing acute cellular toxicity or by inducing a general disruption in translation. These studies indicate that Dimethoate may have disrupted steroidogenesis by targeting specific sites within the cell.…”

Evaluating Chemical Interaction Studies for Mixture Risk Assessment

“……”

Effect of coumaphos on cholinesterase activity, hematology, and biochemical blood parameters of bovines in tropical regions of Mexico

“……”

Dimethoate inhibits steroidogenesis by disrupting transcription of the steroidogenic acute regulatory (StAR) gene

“…In fact, as StAR is a cycloheximide-sensitive protein, a general reduction in protein synthesis could have explained the decrease in StAR protein levels and thus steroid production (Garren et al 1965). However, Dimethoate at concentrations as high as 100 µg/ml failed to affect total protein synthesis in MA-10 cells (this study) or in the human leukemia cell line, HL-60 (Marinovich et al 1994), indicating that it did not inhibit steroidogenesis by causing acute cellular toxicity or by inducing a general disruption in translation. These studies indicate that Dimethoate may have disrupted steroidogenesis by targeting specific sites within the cell.…”

Evaluating Chemical Interaction Studies for Mixture Risk Assessment

“……”

Effect of coumaphos on cholinesterase activity, hematology, and biochemical blood parameters of bovines in tropical regions of Mexico

“……”