Mixture toxicity of three toxicants with similar and dissimilar modes of action to Daphnia magna

Syberg, Kristian; Elleby, Anders; Pedersen, Henrik; Cedergreen, Nina; Forbes, Valery E.

doi:10.1016/j.ecoenv.2007.05.010

Cited by 90 publications

(59 citation statements)

References 40 publications

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“…4 The mixture concentrationresponse relationship of five rays for three sets of binary mixtures where the circle (○) refers to the experimental points, solid line (--) to CRC fitted, dash-dot line (-⋅-⋅) to 95% confidence interval, dash line (--) to the response predicted by CA, and dot line (⋅⋅⋅⋅) to the response predicted by IA Syberga et al 2008). Most studies on the mixture toxicity were finished by the comparison with CA in terms of the toxicity unit (TU) at 50% effect level.…”

Section: Discussionmentioning

confidence: 99%

A novel direct equipartition ray design (EquRay) procedure for toxicity interaction between ionic liquid and dichlorvos

Dou

Liu

et al. 2010

Environ Sci Pollut Res

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Section: Discussionmentioning

confidence: 99%

A novel direct equipartition ray design (EquRay) procedure for toxicity interaction between ionic liquid and dichlorvos

Dou

Liu

et al. 2010

Environ Sci Pollut Res

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“…IL1 IL2 IL3 IL4 IL5 IL6 IL7 IL8 IL9 IL10 IL11 Obs CA IA TSP IL1 IL2 IL3 IL4 IL5 IL6 IL7 IL8 IL9 IL10 To use the TSP method effectively, it should be ensured that the concentrations and CRC models of mixture components are known, the inverse functions of component CRC models are available, and the effects can be normalized to 0-100% range. Unfortunately, the MoAs of chemicals are unknown in most cases, and sometimes one chemical may have several MoAs [32]. So it is unrealistic to determine the specific MoAs for various components.…”

Section: Mixture Toxicitymentioning

confidence: 99%

Two-Stage Prediction of the Effects of Imidazolium and Pyridinium Ionic Liquid Mixtures on Luciferase

Liu

et al. 2014

Molecules

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Abstract:The predicted toxicity of mixtures of imidazolium and pyridinium ionic liquids (ILs) in the ratios of their EC 50 , EC 10 , and NOEC (no observed effect concentration) were compared to the observed toxicity of these mixtures on luciferase. The toxicities of EC 50 ratio mixture can be effectively predicted by two-stage prediction (TSP) method, but were overestimated by the concentration addition (CA) model and underestimated by the independent action (IA) model. The toxicities of EC 10 ratio mixtures can be basically predicted by TSP and CA, but were underestimated by IA. The toxicities of NOEC ratio mixtures can be predicted by TSP and CA in a certain concentration range, but were underestimated by IA. Our results support the use of TSP as a default approach for predicting the combined effect of different types of ILs at the molecular level. In addition, mixtures of ILs mixed at NOEC and EC 10 could cause significant effects of 64.1% and 97.7%, respectively. Therefore, we should pay high attention to the combined effects in mixture risk assessment.

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“…Notice that this approach already proved to be very useful (Belz, Cedergreen, and Sørensen 2008;Syberg et al 2007;Christensen et al 2007), but it was never documented properly statistically. In particular, the method was very convenient for the hormesis study in Belz, Cedergreen, and Sørensen (2008) because a few particular effect levels were of main interest and because no response surface model including hormesis is available at present.…”

Section: Introductionmentioning

confidence: 95%

A Random Effects Model for Binary Mixture Toxicity Experiments

Sørensen

Cedergreen

Streibig

2010

JABES

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We suggest a simple isobole analysis for binary mixture toxicity experiments. The analysis is based on estimated logarithmic effect concentrations and their corresponding standard errors. The suggested model allows for synergism/antagonism and incorporates within-mixture variation as well as between-mixture variation in a random effects model. The likelihood ratio test for the hypothesis of concentration addition (CA) is examined, in particular its small sample properties. We study two datasets on the joint effect of acifluorfen versus diquat and glyphosate versus mechlorprop, respectively, on the growth of the aquatic macrophyte Lemna minor.

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Mixture toxicity of three toxicants with similar and dissimilar modes of action to Daphnia magna

Cited by 90 publications

References 40 publications

A novel direct equipartition ray design (EquRay) procedure for toxicity interaction between ionic liquid and dichlorvos

A novel direct equipartition ray design (EquRay) procedure for toxicity interaction between ionic liquid and dichlorvos

Two-Stage Prediction of the Effects of Imidazolium and Pyridinium Ionic Liquid Mixtures on Luciferase

A Random Effects Model for Binary Mixture Toxicity Experiments

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