Mixed tumors of the canine mammary glands: Evaluation of prognostic factors, treatment, and overall survival

Nunes, Fernanda Camargo; Damasceno, Karine Araújo; Campos, Cecília Bonolo de; Bertagnolli, Angélica Cavalheiro; Lavalle, Gleidice Eunice; Cassali, Geovanni Dantas

doi:10.1016/j.vas.2018.09.003

Cited by 26 publications

(41 citation statements)

References 32 publications

(49 reference statements)

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“…Canadas et al (2018) found that, of 144 tumors, the most frequent type was complex carcinoma (49/144). For Nunes et al (2019), 75% (682/904) of the cases were carcinoma in a mixed tumor, which corroborates this study. In addition, other histological types were found, however in lesser number when compared to carcinoma in a mixed tumor.…”

Section: Discussionsupporting

confidence: 90%

Relationship of obesity with clinical and laboratory changes in female dogs with mammary neoplasia

et al. 2020

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Obesity may be associated with the onset of mammary tumors in women. In companion animals, these data are still scarce, mainly associating the clinic of the patient with laboratory and histological findings. This study aimed to evaluate the clinical and laboratory aspects of female dogs with mammary neoplasia, investigating whether they are related to obesity. Four groups of spayed or non-spayed female dogs were studied, divided into (G1) female dogs without mammary tumor and normal body condition score (BCS), (G2) female dogs without mammary tumor and obese, (G3) female dogs with mammary tumor and normal BCS and (G4) female dogs with mammary tumor and obese. BCS, canine body mass index (CBMI), blood count, glucose, total cholesterol, triglycerides and cytopathological and histopathological examinations were evaluated. Mixed-breed animals were the most prevalent in this study (67.5%). There was a limitation regarding the use of CBMI related to body proportionality. Considering the 28 tumors evaluated, carcinoma in mixed tumor was the most prevalent malignant histological type, while adenomyoepithelioma was the most prevalent benign histological type. It was possible to conclude that obesity was not related to clinical and laboratory changes in the female dogs affected with mammary neoplasias. In addition, no relationship was noted between BCS and CBMI with the histological type or malignancy of mammary neoplasia, since the malignant histological types were the most prevalent tumors in both the ideal score group and the overweight to obese group.

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Section: Discussionsupporting

confidence: 90%

Relationship of obesity with clinical and laboratory changes in female dogs with mammary neoplasia

et al. 2020

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“…Mammary gland tumors are one of the most common cancers in dogs, especially in non-spayed females, and are still one of the leading causes of death among canines [1][2][3]. Interestingly, canine mammary tumors are an attractive and useful model for studying human breast cancer.…”

Section: Introductionmentioning

confidence: 99%

The Expression of Selected Factors Related to T Lymphocyte Activity in Canine Mammary Tumors

Bujak

Szopa

Pingwara

et al. 2020

IJMS

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Crosstalk between neoplastic and immune cells in the tumor microenvironment (TME) influences the progression of disease in human and canine cancer patients. Given that canine mammary tumors are a useful model to study breast cancer biology, we aimed to evaluate the expression of genes associated with T lymphocyte activity in benign, malignant, and metastatic canine mammary tumors. Interestingly, metastatic tumors exhibit increased expression of CXCR3, CCR2, IL-4, IL-12p40, and IL-17. In particular, we focused on IL-17, a key interleukin associated with the Th17 lymphocyte phenotype. Th17 cells have been shown to play a contradictory role in tumor immunity. Although IL-17 showed a high expression in the metastatic tumors, the expression of RORγt, a crucial transcription factor for Th17 differentiation was barely detected. We further investigated IL-17 expression using immunohistochemistry, through which we confirmed the increased expression of this interleukin in malignant and metastatic mammary tumors. Finally, we compared the plasma levels of IL-17 in healthy and malignant mammary tumor-bearing dogs using ELISA but found no differences between the groups. Our data indicate that the IL-17 in metastatic tumors may be produced by other cell types, but not by Th17 lymphocytes. Overall, our results broaden the available knowledge on the interactions in canine mammary tumors and provide insight into the development of new therapeutic strategies, with potential benefits for human immune oncology.

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“…Mixed mammary carcinosarcoma is an uncommon type of neoplasm in the animals because of consist malignant of differentiated cells and aggressive behaviour (Nunes et al, 2019). It has a high vascularisation sustains the abnormal proliferative cells to receive nutrition (Gal et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Mixed Mammary Carcinosarcoma in Domesticated Asian Palm Civet (Paradoxurus hermaphroditus).

Prakoso¹,

Widyawati²,

Wirjaatmadja³

et al. 2019

jwpr

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A female Asian palm civet (Paradoxurus hermaphroditus), three years old was carried for a medical checkup to Ruddy animal's clinic in Sidoarjo, East Java, Indonesia. The civet suffers enlargement of abdominal mammary glands, painless lump, asymmetric size (4.1 and 8.4 cm in diameter), and lacerated wound on the large one with severe haemorrhage. The unilateral mastectomy was conducted under anaesthesia to handles both haemorrhage and tumour mass. Following the surgery, the tumour mass was stored in 10% neutral buffer formalin for histopathology using Hematoxylin & Eosin (H&E) staining and immunohistochemistry against antibody, anti-CD4+ and CD8+, further, a blood sample collected before and after surgery (on days: 0, 7, 30, and 60) for representing the healing progress. The chemotherapy was given using the combination of oral cyclophosphamide and intravenous injection of vincristine. According to laboratory results, the final diagnosis was mixed mammary carcinosarcoma with minimal expression of CD8+, notwithstanding, it showed the better prognosis after surgery and chemotherapy.

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Mixed tumors of the canine mammary glands: Evaluation of prognostic factors, treatment, and overall survival

Cited by 26 publications

References 32 publications

Relationship of obesity with clinical and laboratory changes in female dogs with mammary neoplasia

Relationship of obesity with clinical and laboratory changes in female dogs with mammary neoplasia

The Expression of Selected Factors Related to T Lymphocyte Activity in Canine Mammary Tumors

Mixed Mammary Carcinosarcoma in Domesticated Asian Palm Civet (Paradoxurus hermaphroditus).

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