Abstract:<p></p><p>The
peptide α-helix is right-handed when containing amino acids with L-chirality,
and left-handed with D-chirality, however mixed chirality peptides generally do
not form α-helices unless the non-natural residue amino-isobutyric acid is used
as helix inducer. Herein we report the first X-ray crystal structures of mixed
chirality α-helices in short peptides comprising only natural residues at the
example of a stapled bicyclic and a linear membrane disruptive amphiphilic antimicrobial… Show more
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