Mixed cellularity classical Hodgkin lymphoma (MCcHL)

Abstract

Over the past 50 years, a relevant progress has been made toward our understanding of classical Hodgkin lymphoma pathology and cell biology. Histologic classification evolved through different systems to the 2008 World Health Organization classification, upgraded in 2016. Mixed cellularity is a subtype of classical Hodgkin lymphoma characterized by diagnostic HodgkinReed Sternberg cells in a mixed inflammatory background without sclerosis. Mononuclear Hodgkin cells can be present. The mixed cellular background is considered the hallmark of the Mixed cellularity classical Hodgkin lymphoma subtype. In particular, heterogeneous constituents including admixed eosinophils plasma cells, histiocytes and small lymphocytes are usually found. The composition of this background varies greatly.