Mixed allergic bronchopulmonary fungal disease due to Pseudallescheria boydii and Aspergillus.

Lake, F R; Tribe, Anthony E; McAleer, Rose; Froudist, J H; Thompson, P.

doi:10.1136/thx.45.6.489

Cited by 44 publications

(23 citation statements)

References 9 publications

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“…A major aim of this study was to determine whether this antigen could be useful for diagnostic purposes, mainly in mixed allergic bronchopulmonary fungal disease due to P. boydii and Aspergillus (Lake et al, 1990). The chemical characterization of fungal antigens is important to allow a rational interpretation of the cross-reactivity between pathogenic species, thus helping to select immunodominant components that can be of diagnostic use.…”

Section: Discussionmentioning

confidence: 99%

“…P. boydii resembles other fungal species in tissue specimens and is not easily distinguished from Aspergillus species. Antibody levels and skin tests may help diagnosis of these fungi, particularly if allergic disease is suspected (Lake et al, 1990). Very few studies on the antigenic composition and the immune response elicited during infection by P. boydii have been reported.…”

Section: Introductionmentioning

confidence: 99%

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A peptidorhamnomannan from the mycelium of Pseudallescheria boydii is a potential diagnostic antigen of this emerging human pathogen

et al. 2001

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The ascomycete Pseudallescheria boydii is an emerging human pathogen frequently found in soil and polluted water. A peptidopolysaccharide antigen has been isolated from mycelial forms of P. boydii, and characterized using chemical and immunological methods. Monosaccharide composition, methylation analysis, and 1 H-and 13 C-NMR spectra indicated the presence of a rhamnomannan with a structure distinct from those of similar components isolated from other fungi, containing Rhap(1 3)Rhap epitopes on side chains which may be linked (1 3) to (1 6)-linked mannose. The peptidorhamnomannan from P. boydii reacted poorly with an antiserum raised against whole cells of Sporothrix schenckii and strongly with one against P. boydii hyphae. These characteristics and immunological differences suggest that this major rhamnose-containing antigen of P. boydii may be useful for the specific diagnosis of infections attributable to this fungus.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A peptidorhamnomannan from the mycelium of Pseudallescheria boydii is a potential diagnostic antigen of this emerging human pathogen

et al. 2001

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“…Fungus balls in preexisting cavities can be seen in otherwise normal hosts, but invasive disease is usually limited to immunosuppressed patients (8,68,277,376,448,482,485). In the saprobic state, although some patients may have no or minimal symptoms, some may develop pulmonary infiltrates and even fungus balls with or without symptoms (483), and others develop an allergic reaction to the presence of the fungus (232,294,357).…”

Section: Saprobic Involvement/colonization Of Airwaysmentioning

confidence: 99%

“…The second case was in a patient with recurrent allergic bronchopulmonary aspergillosis with an exacerbation of ABPM caused by Pseudallescheria boydii. The third case was in a patient on chronic corticosteroid therapy for rheumatoid arthritis who intermittently expectorated P. boydii while on corticosteroid therapy (232,294,357). FIG.…”

Section: Epidemiology Of Human Infectionsmentioning

confidence: 99%

Infections Caused byScedosporiumspp

et al. 2008

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SUMMARY Scedosporium spp. are increasingly recognized as causes of resistant life-threatening infections in immunocompromised patients. Scedosporium spp. also cause a wide spectrum of conditions, including mycetoma, saprobic involvement and colonization of the airways, sinopulmonary infections, extrapulmonary localized infections, and disseminated infections. Invasive scedosporium infections are also associated with central nervous infection following near-drowning accidents. The most common sites of infection are the lungs, sinuses, bones, joints, eyes, and brain. Scedosporium apiospermum and Scedosporium prolificans are the two principal medically important species of this genus. Pseudallescheria boydii, the teleomorph of S. apiospermum, is recognized by the presence of cleistothecia. Recent advances in molecular taxonomy have advanced the understanding of the genus Scedosporium and have demonstrated a wider range of species than heretofore recognized. Studies of the pathogenesis of and immune response to Scedosporium spp. underscore the importance of innate host defenses in protection against these organisms. Microbiological diagnosis of Scedosporium spp. currently depends upon culture and morphological characterization. Molecular tools for clinical microbiological detection of Scedosporium spp. are currently investigational. Infections caused by S. apiospermum and P. boydii in patients and animals may respond to antifungal triazoles. By comparison, infections caused by S. prolificans seldom respond to medical therapy alone. Surgery and reversal of immunosuppression may be the only effective therapeutic options for infections caused by S. prolificans.

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“…Immunocompromised patients, including those with hematological malignancy or undergoing bone marrow or solid-organ transplantation, may suffer fatal pulmonary, sinus, and disseminated infections (4,5,10,13). Patients with cavitating or chronic suppurative lung diseases may develop clinical problems similar to those caused by Aspergillus fumigatus, the most common being respiratory tract colonization; fungal balls (7) and allergic bronchopulmonary disease (9) have also been reported. S. apiospermum is usually resistant in vitro and in vivo to commonly available antifungal agents, such as itraconazole and amphotericin.…”

mentioning

confidence: 99%

Molecular Epidemiology of Scedosporium apiospermum Infection Determined by PCR Amplification of Ribosomal Intergenic Spacer Sequences in Patients with Chronic Lung Disease

et al. 2001

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Respiratory tract colonization with Scedosporium apiospermum in patients with chronic suppurative lung disease is a significant concern for lung transplantation candidates, since Scedosporium infections occurring posttransplantation are usually untreatable. Up to 10% of patients with cystic fibrosis attending our respiratory medicine unit have had Scedosporium organisms isolated from sputum samples. We therefore developed a molecular typing method to examine these isolates. Typing by PCR amplification of ribosomal intergenic spacer sequences demonstrated 20 different types from 52 isolates collected from the respiratory medicine unit and elsewhere in Australia. A single common type was isolated from 11 respiratory medicine unit inpatients. Two other types were isolated from more than one source: one from two respiratory medicine unit inpatients and one from two epidemiologically linked nonhuman sources. Multiple isolates were obtained from nine patients. This method demonstrated persistent carriage of isolates of the same type in one patient for 7 months. Two patients showed carriage of isolates with multiple typing patterns within a 3-month period. The high rate of isolation and the predominance of isolates with a single typing pattern from respiratory medicine unit patients may suggest transmission to patients from a source in the unit. There was no epidemiological evidence of direct patient-to-patient spread, and Scedosporium organisms were not isolated from dust, soil, or air samples from the unit. The source and route of transmission have yet to be determined.

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Mixed allergic bronchopulmonary fungal disease due to Pseudallescheria boydii and Aspergillus.

Cited by 44 publications

References 9 publications

A peptidorhamnomannan from the mycelium of Pseudallescheria boydii is a potential diagnostic antigen of this emerging human pathogen

A peptidorhamnomannan from the mycelium of Pseudallescheria boydii is a potential diagnostic antigen of this emerging human pathogen

Infections Caused byScedosporiumspp

Molecular Epidemiology of Scedosporium apiospermum Infection Determined by PCR Amplification of Ribosomal Intergenic Spacer Sequences in Patients with Chronic Lung Disease

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