Mitotic activity of cells in the fibrous zone of the rat mandibular condyle

Mizuno, Isao; Saburi, Noriaki; Taguchi, Nozomu; Kaneda, Toshio; Hoshino, Takao

doi:10.1016/0003-9969(92)90149-3

Cited by 5 publications

(1 citation statement)

References 13 publications

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“…Several ultrastructural studies using normal human [Ben-Ami et al, 1992] and animal condylar cartilage [Silva, 1967;Appleton, 1975Appleton, , 1978Silbermann and Lewinson, 1978;Luder et al, 1988;Livne et al, 1990;Marchi et al, 1991] have shown that normal condylar cartilage is composed primarily of three layers, a perichondrium which is a fibroelastic connective tissue composed of fibroblasts, undifferentiated mesenchymal cells, type I collagen and elastic fibers [Wilson and Gardner, 1984;De Bont et al, 1984, 1985Mizuno et al, 1992;Missankov, 1995;Klinge, 1996], a hyaline cartilage composed of chondrocytes located in lacunae, two or more cells are enclosed in a capsule or a chondron. Chondrons are connected by pericellular channels [Broom and Myers, 1980;Broom and Poole 1982;Poole et al, 1982Poole et al, , 1984Poole et al, , 1991.…”

Section: Introductionmentioning

confidence: 99%

Ultrastructural Characterization of the Rabbit Mandibular Condyle following Experimental Induction of Anterior Disk Displacement

Sharawy¹,

Ali

Choi³

et al. 2000

Cells Tissues Organs

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Previous studies in our laboratory have shown that surgical induction of anterior disk displacement (ADD) in the rabbit craniomandibular joint (CMJ) leads to cellular and extracellular alterations consistent with osteoarthritis. Similar findings were also reported in human ADD as well as osteoarthritis of other joints. The purpose of this study was to further characterize these histopathological findings at the ultrastructural level. The right joint of 15 rabbits was exposed surgically and all discal attachments were severed except for the posterior attachment. The disk was then repositioned anteriorly and sutured to the zygomatic arch. The left joint served as a sham-operated control. Ten additional joints were used as nonoperated controls. Mandibular condyles were excised 2 weeks following surgery and processed for transmission electron microscopy. Experimental condyles showed neovascularization, fibrillation and vacuolation of the extracellular matrix and an increase in the number of apoptotic cells compared to controls. In addition, chondrocytes in osteoarthritic cartilage showed an increase in the amounts of rough endoplasmic reticulum and Golgi complex suggesting an increase in protein synthesis. The presence of thick collagen fibers in osteoarthritic cartilage supports our previous immunohistochemical results of the presence of type I collagen instead of normally existing type II collagen. It was concluded that surgical induction of ADD in the rabbit CMJ leads to ultrastructural changes in the mandibular condylar cartilage consistent with degenerative alterations known to occur in osteoarthritis.

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