2020
DOI: 10.21203/rs.3.rs-48449/v1
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Mitophagy Promotes Sorafenib Resistance Through a Hypoxia-Inducible ATAD3A Dependent Axis

Abstract: BACKGROUND: The identification of novel targets for recovering sorafenib resistance is pivotal for Hepatocellular carcinoma (HCC) patients. Mitophagy is the programmed degradation of mitochondria, and is likely involved in drug resistance of cancer cells. Here we identified hyperactivated mitophagy is essential for sorafenib resistance, and the mitophagy core regulator gene ATAD3A (ATPase family AAA domain containing 3A) was down regulated in the resistant hepatoma cells. Blocking mitophagy may restore the sor… Show more

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