2017
DOI: 10.18632/aging.101350
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Abstract: Using a systems-based approach, we have identified several genes not previously evaluated for a role(s) in chronological aging. Here, we have thoroughly investigated the chronological lifespan (CLS) of three of these genes (FUS3, KSS1 and HOG1) and their protein products, each of which have well-defined cell signaling roles in young cells. The importance of FUS3 and KSS1 in CLS are largely unknown and analyzed here for the first time. Using both qualitative and quantitative CLS assays, we show that deletion of… Show more

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Cited by 9 publications
(5 citation statements)
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References 75 publications
(118 reference statements)
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“…S. cerevisiae encodes seven phosphatases in the type 2C Ser/Thr phosphatase (PP2C) superfamily (Ptc1-Ptc7) ( Ariño et al, 2011 ), and Ptc1, Ptc2, and Ptc3 are negative regulators of MAPK ( Warmka et al, 2001 ). In deficiencies of the MAPK pathway, cells elevate their stress tolerance ability to extend CLS ( Aluru et al, 2017 ). Although currently there is no direct evidence that PP2C may control stress tolerance through the MAPK pathway, our study provides a means by which PP2C governs stress tolerance: PP2C removes PKA-mediated Ids2 phosphorylation to maintain ample chaperone activity.…”
Section: Discussionmentioning
confidence: 99%
“…S. cerevisiae encodes seven phosphatases in the type 2C Ser/Thr phosphatase (PP2C) superfamily (Ptc1-Ptc7) ( Ariño et al, 2011 ), and Ptc1, Ptc2, and Ptc3 are negative regulators of MAPK ( Warmka et al, 2001 ). In deficiencies of the MAPK pathway, cells elevate their stress tolerance ability to extend CLS ( Aluru et al, 2017 ). Although currently there is no direct evidence that PP2C may control stress tolerance through the MAPK pathway, our study provides a means by which PP2C governs stress tolerance: PP2C removes PKA-mediated Ids2 phosphorylation to maintain ample chaperone activity.…”
Section: Discussionmentioning
confidence: 99%
“…In the model fungus, Saccharomyces cerevisiae , five important cellular development events, namely sporulation, cell wall integrity, osmoregulation, sexual mating, and filamentous (pseudohyphal) growth, have been shown to be regulated respectively by five established MAPK pathways ( Chen and Thorner, 2007 ; Vallejo and Mayinger, 2015 ). Specifically, S. cerevisiae Hog1 is integral to the osmoregulatory signal transduction cascade ( Nancy et al, 2015 ), Fus3/Kss1 are essential for sexual reproduction and regulate chronological life span ( Maneesha et al, 2017 ), and MPK1 is involved in cell wall integrity ( Kim et al, 2018 ). In addition, a specialized type of MAPKs in fungi and mammalian was termed as stress-activated protein kinases (SAPKs), as it is responsible for stress response, including heat shock, hyperosmolarity, ultraviolet (UV) light irradiation, and oxidative stress ( Brown et al, 2014 ).…”
Section: Introductionmentioning
confidence: 99%
“…This negative regulator role of Ptc4 may contribute to rapid cell proliferation. Moreover, deletion of HOG1 in S. cerevisiae extends CLS and confers thermal and oxidative stress tolerances 49 , 58 , suggesting that inactivation of Hog1 through dephosphorylation by Ptc4 contributes to CLS extension and stress tolerance for long-term cell survival. In the case of Zwf1, its overexpression may enhance the pentose phosphate pathway to generate reduced nicotinamide adenine dinucleotide phosphate (NADPH) 59 , 60 .…”
Section: Discussionmentioning
confidence: 99%