2019
DOI: 10.1002/mrd.23129
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Abstract: Female fertility declines dramatically over the age of 35 due to age-related decreases in oocyte quality and quantity. Although mitochondrial transfer promises to be a technology that can improve the quality of such age-impaired oocytes, the ideal mitochondrial donor remains elusive. In the present study, we aimed to identify whether aged adipose-derived stem cells constitute an excellent mitochondrial donor that would improve the quality of aged mouse oocytes. We showed that aging significantly impaired the m… Show more

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Cited by 18 publications
(30 citation statements)
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“…Mitochondrial disease and senile infertility, especially those with aging oocytes, are both closely related to mitochondrial dysfunction ( 30 39 ). Currently, the treatment methods mainly include complementary therapies such as the supplement of Coenzyme Q10, NAD, Growth Hormone and other substances that can enhance mitochondrial function ( 40 43 ), mitochondrial transfer from aged adipose-derived stem cells ( 44 ) and autologous mitochondrial transfer ( 45 , 46 ), which can only temporarily relieve symptoms, while ST can fundamentally eliminate the influence of abnormal mitochondria. Thus, ST is considered to be the most valuable therapeutic strategy for clinical transformation.…”
Section: Discussionmentioning
confidence: 99%
“…Mitochondrial disease and senile infertility, especially those with aging oocytes, are both closely related to mitochondrial dysfunction ( 30 39 ). Currently, the treatment methods mainly include complementary therapies such as the supplement of Coenzyme Q10, NAD, Growth Hormone and other substances that can enhance mitochondrial function ( 40 43 ), mitochondrial transfer from aged adipose-derived stem cells ( 44 ) and autologous mitochondrial transfer ( 45 , 46 ), which can only temporarily relieve symptoms, while ST can fundamentally eliminate the influence of abnormal mitochondria. Thus, ST is considered to be the most valuable therapeutic strategy for clinical transformation.…”
Section: Discussionmentioning
confidence: 99%
“…A clinical trial has proposed that using autologous cumulus granulosa cells as mitochondria donor cells can rescue aged oocytes and obtain live births 12 . But the problem is that these somatic cells also age with oocyte aging 13 .…”
Section: Discussionmentioning
confidence: 99%
“…It has been reported that mitochondria from autologous adiposederived stem cells (ADSCs) have normal morphology and can improve oocyte quality and infertility in aged mice 19 . Nevertheless, another investigation using mitochondria from autologous ADSCs has reached a conflicting conclusion 13 . Therefore, adult ADSCs are not necessarily a suitable mitochondria source.…”
Section: Discussionmentioning
confidence: 99%
“…The raw number of follicles was multiplied by five to determine the total number of follicles, as the sampling fraction with respect to every 5th section being counted. The follicles were classified according to the classification system used by previous studies [ 18 ].…”
Section: Methodsmentioning
confidence: 99%