2001
DOI: 10.1080/15216540152845984
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Abstract: SummaryMost of the oxygen consumed by aerobic organisms is reduced to water by the enzyme cytochrome c oxidase in the terminal reaction of the mitochondrial respiratory chain. A signi cant proportion of the oxygen molecules are converted to superoxide anion radicals by complexes I and III via a nonenzymatic process. A cascade of enzymes, some of them inside the mitochondria themselves, scavenges superoxide anions in order to protect cells from oxidative damage induced by reactive oxygen species (ROS). Unfortun… Show more

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Cited by 157 publications
(98 citation statements)
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References 72 publications
(77 reference statements)
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“…Mitochondrial uncoupling proteins are localized to the inner mitochondrial membrane where they translocate protons from the intermembrane space to the mitochondrial matrix and thus reduce the driving force for ATP synthesis, dissipate energy in the form of heat, and decrease production of superoxide (Cannon et al, 2006;Casteilla et al, 2001;Erlanson-Albertsson, 2003;Rousset et al, 2004). Uncoupling proteins show neuroprotective effects, underscoring the importance of reducing mitochondrial ROS for preventing brain damage (Mattiasson et al, 2003) Chan et al, 2006.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Mitochondrial uncoupling proteins are localized to the inner mitochondrial membrane where they translocate protons from the intermembrane space to the mitochondrial matrix and thus reduce the driving force for ATP synthesis, dissipate energy in the form of heat, and decrease production of superoxide (Cannon et al, 2006;Casteilla et al, 2001;Erlanson-Albertsson, 2003;Rousset et al, 2004). Uncoupling proteins show neuroprotective effects, underscoring the importance of reducing mitochondrial ROS for preventing brain damage (Mattiasson et al, 2003) Chan et al, 2006.…”
Section: Discussionmentioning
confidence: 99%
“…Mitochondrial uncoupling proteins (UCPs) significantly modulate mitochondrial ROS production (Cannon et al, 2006;Casteilla et al, 2001;Rousset et al, 2004). We tested the hypothesis that gonadal hormones affect one or more of three isoforms important in the brain: UCP-2, 4 and 5 (Chan et al, 2006;Ho et al, 2006;Mattiasson et al, 2003).…”
Section: Effect Of Sex Hormones On Brain Mitochondrial Uncoupling Promentioning
confidence: 99%
“…However, the largest source of free radicals is the process of oxidative phosphorylation. Estimates of the rate at which oxygen radicals are generated during oxidative phosphorylation are frequently quoted as being up to 3% of the inspired oxygen (Beckman and Ames, 1998;Castiella et al, 2001;Golden and Melov, 2001;AcunaCastroviejo et al, 2001). More recently, however, these estimates have been questioned and it is likely that the actual productions are much lower -of the order of 0.1% (St Pierre et al, 2002).…”
Section: Historical Perspectivementioning
confidence: 99%
“…B. Dans les cellules qui expriment UCP1, cette protéine s'insère sous forme dimérique dans la membrane interne et agit comme un canal à protons qui dissipe le gradient électrochimique dû au fonctionnement de la chaîne respiratoire sans permettre la synthèse d'ATP : l'énergie sera libérée sous forme de chaleur, la respiration est découplée de la synthèse d'ATP. L'activité d'UCP1 est contrôlée de manière importante par le coenzyme Q, ce qui pourrait suggérer que dans les mitochondries qui contiennent ce type de protéines, celles-ci font partie intégrante de la chaîne respiratoire et permettraient une régulation fine et complexe du fonctionnement de celle-ci [16]. UQ : ubiquinone ; cyt-c : cytochrome c. [10].…”
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