2021
DOI: 10.3389/fmed.2021.745279
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Abstract: The role and nature of mitochondrial dysfunction in diabetic kidney disease (DKD) has been extensively studied. Yet, the molecular drivers of mitochondrial remodeling in DKD are poorly understood. Diabetic kidney cells exhibit a cascade of mitochondrial dysfunction ranging from changes in mitochondrial morphology to significant alterations in mitochondrial biogenesis, biosynthetic, bioenergetics and production of reactive oxygen species (ROS). How these changes individually or in aggregate contribute to progre… Show more

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Cited by 17 publications
(12 citation statements)
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“…Taken together, these results suggested that AKAP1/Larp1 signaling mediated the impairment in mtDNA replication and mitochondrial dysfunction via PKC activation in podocytes of DKD. DKD, which is the major cause of chronic kidney disease (CKD) and end stage renal disease (ESRD), is closely related to mitochondrial dysfunction, including mitochondrial dynamics, bioenergetics, biosynthesis, mitophagy, oxidative stress and mtDNA disorders [28][29][30]. Likewise, we confirmed impaired ATP synthesis and ROS overproduction in DKD.…”
Section: Discussionsupporting
confidence: 70%
“…Taken together, these results suggested that AKAP1/Larp1 signaling mediated the impairment in mtDNA replication and mitochondrial dysfunction via PKC activation in podocytes of DKD. DKD, which is the major cause of chronic kidney disease (CKD) and end stage renal disease (ESRD), is closely related to mitochondrial dysfunction, including mitochondrial dynamics, bioenergetics, biosynthesis, mitophagy, oxidative stress and mtDNA disorders [28][29][30]. Likewise, we confirmed impaired ATP synthesis and ROS overproduction in DKD.…”
Section: Discussionsupporting
confidence: 70%
“…[ 39 ]). Many of these processes are known to have been linked to the development and pathogenesis of DKD [ 6 , 10 , [40] , [41] , [42] ].…”
Section: Discussionmentioning
confidence: 99%
“…Much of the prior focus was placed on the superoxide radical anion, as the primary form of reactive oxygen species (ROS) produced mostly by mitochondria [ 5 , 6 ] or NADPH oxidases [ 7 ]. Indeed, overproduction of mitochondrial superoxide as a major form of oxidative stress and a primary event in diabetic/chronic kidney disease has been postulated [ 6 , [8] , [9] , [10] , [11] ]. Very often, the umbrella term “ROS” is also used to define several reactive species together with different kinetics and compartmentalization properties [ 12 ].…”
Section: Introductionmentioning
confidence: 99%
“…4 High blood glucose concentration and ROS have also been reported to alter mitochondrial functions in the liver and kidney of diabetic patients. 5,6,7 Mitochondrial dysfunction is a major factor that triggers β-cell dysfunction and malfunctioning of insulin signaling pathways in the cell. 8,9 Mitochondrial dysfunction which occurs as a result of excessive ROS production is potent in inducing the opening of the mitochondrial membrane permeability pore.…”
Section: Introductionmentioning
confidence: 99%