J. Neurosci. Res. volume 86, issue 5, P961-971 2008 DOI: 10.1002/jnr.21564 View full text
Junghee Lee, Swati Sharma, Jinho Kim, Robert J. Ferrante, Hoon Ryu

Abstract: Mitochondria are power organelles generating biochemical energy, ATP, in the cell. Mitochondria play a variety of roles, including integrating extracellular signals and executing critical intracellular events, such as neuronal cell survival and death. Increasing evidence suggests that a cross-talk mechanism between mitochondria and the nucleus is closely related to neuronal function and activity. Nuclear receptors (estrogen receptors, thyroid (T3) hormone receptor, peroxisome proliferators-activated receptor g…

expand abstract