Eunsung Junn, Won Hee Jang, Xin Zhao, Byeong Seon Jeong, M. Maral Mouradian
AbstractMutations in DJ-1 (PARK7) cause recessively inherited Parkinson's disease. DJ-1 is a multifunctional protein with anti-oxidant and transcription modulatory activity. Its localization in cytoplasm, mitochondria and nucleus is recognized, but the relevance of this sub-cellular compartmentalization to its cytoprotective activity is not fully understood. Here we report that at basal conditions DJ-1 is present mostly in the cytoplasm and to a lesser extent in mitochondria and nucleus of dopaminergic neurob…
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