Journal of Cell Biology volume 217, issue 1, P139-149 2017 DOI: 10.1083/jcb.201702125 View full text
|
|
Share
Xi Wu, Lanlan Li, Hui Jiang

Abstract: The turnover of mitochondrial outer-membrane proteins is known to be mediated by the cytoplasmic ubiquitin–proteasome pathway. Wu et al. report the unexpected finding that two outer-membrane proteins Tom22 and Om45 are inwardly translocated into mitochondria and degraded by the inner-membrane protease Yme1.