2015
DOI: 10.18632/aging.100832
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Abstract: Fasting promotes longevity by reprogramming metabolic and stress resistance pathways. However, although the impact on adipose tissue physiology through hormonal inputs is well established, the direct role of fasting on adipose cells is poorly understood. Herein we show that white and beige adipocytes, as well as mouse epididymal and subcutaneous adipose depots, respond to nutrient scarcity by acquiring a brown-like phenotype. Indeed, they improve oxidative metabolism through modulating the expression of mitoch… Show more

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Cited by 30 publications
(40 citation statements)
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References 42 publications
(73 reference statements)
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“…Two mitochondrial dyes, MitoTracker Green FM and MitoTracker Red CMXRos (Thermo Fisher Scientific), were used to estimate mitochondrial mass and membrane potential (Pendergrass et al, 2004; Cottet-Rousselle et al, 2011; Martins et al, 2015; Henzi and Schwaller, 2015; Barbato et al, 2015). Fluorescence microscopy confirmed that both dyes stained the mitochondria with very little background staining of the cytosol (data not shown).…”
Section: Methodsmentioning
confidence: 99%
“…Two mitochondrial dyes, MitoTracker Green FM and MitoTracker Red CMXRos (Thermo Fisher Scientific), were used to estimate mitochondrial mass and membrane potential (Pendergrass et al, 2004; Cottet-Rousselle et al, 2011; Martins et al, 2015; Henzi and Schwaller, 2015; Barbato et al, 2015). Fluorescence microscopy confirmed that both dyes stained the mitochondria with very little background staining of the cytosol (data not shown).…”
Section: Methodsmentioning
confidence: 99%
“…CR determines metabolic changes of adipose tissue that may explain its beneficial effects on whole-body homeostasis (22,24,184). Among these effects, CR promotes mitochondrial adaptations and the activation of thermogenesis in adipose tissue (185). At a molecular level, food withdrawal reduces plasma insulin and IGF-1 (186), with subsequent improvement of insulin sensitivity.…”
Section: Impact Of Cr On Aging Pathways In the Adipocytementioning
confidence: 99%
“…Specifically cold exposure directly activates a thermogenic gene program in white and beige adipocytes independently of the canonical cAMP/Protein Kinase A/cAMP response element-binding protein pathway that is downstream of β-adrenergic receptors (Ye et al, 2013). Similarly, nutrient shortage as well as the nutrient restriction mimetic rapamycin, boost mitochondrial metabolism in white and beige adipocytes independently of cAMP/PKA signalling and are equally able to reduce adipocyte size (Barbato et al, 2015;Chakrabarti et al, 2010). Stimulation of β-adrenergic receptors is accompanied by a prominent change in intracellular redox homeostasis that shifts towards a prooxidant status (Lettieri Barbato et al, 2015a).…”
Section: The Light and The Dark Side Of The White Adipose Tissuementioning
confidence: 99%
“…The best practice to recapitulate mitohormesis is nutrient shortage, which promotes a transient mt ROS flux crucial to signal stress defensive program by an evolutionary conserved mechanism (Barbato et al, 2015;Ristow and Schmeisser, 2014). It has been shown that fat cells have the ability to improve oxidative/antioxidant metabolism during fasting and mt ROS are upstream mediator of 14 such response (Barbato et al, 2015;Lettieri Barbato et al, 2014a).…”
Section: Mt Ros Threshold: From Damaging Agents To Signalling Mediatorsmentioning
confidence: 99%
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