“…A similar TPE is conserved in Drosophila , mammals and Trypanosoma [ 135 , 136 , 137 , 138 , 139 , 140 , 141 ]. As in yeast, human TPE is regulated by long-range chromatin loops whose formation depends upon TL and shelterin subunits [ 142 , 143 , 144 , 145 ]. The existence of long-range chromatin-loops has first been described in yeast [ 146 , 147 , 148 , 149 , 150 ], then in plant [ 151 ] and in mammalian cells [ 146 , 147 , 149 , 152 , 153 ].…”