Mitochondrial fission promotes self-renewal and tumorigenic potential in prostate cancer

Civenni, Gianluca; Carbone, Giuseppina M.; Catapano, Carlo V.

doi:10.1080/23723556.2019.1644598

Cited by 2 publications

(1 citation statement)

References 10 publications

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“…Mitochondrial fission also depends upon the availability of ATP and intracellular calcium levels (Kong et al, 2005), where calcineurin, a calcium‐dependent phosphatase, triggers fission events through dephosphorylation of cytosolic DRP1, which leads to its mitochondrial translocation (Cereghetti et al, 2010). Recently, mitochondrial plasticity was found to be a new anti‐cancer target in CSCs of human prostate cancer (Civenni & Carbone, 2019; Passaniti & Hussain, 2019). Bromodomain‐containing protein 4 (BRD4) is one of the bromodomain and extra‐terminal domain (BET) proteins that trigger mitochondrial biogenesis and metabolic plasticity through up‐regulating MFF (DRP1 receptor) in the prostate CSCs.…”

Section: Modulation Of Mitochondrial Dynamics In Cscs: a Necessary Pr...mentioning

confidence: 99%

Dysregulation of mitophagy and mitochondrial homeostasis in cancer stem cells: Novel mechanism for anti‐cancer stem cell‐targeted cancer therapy

Praharaj

Patro

Bhutia

2021

British J Pharmacology

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Despite the potential of cancer medicine, cancer stem cells (CSCs) associated with chemoresistance and disease recurrence are the significant challenges currently opposing the efficacy of available cancer treatment options. Mitochondrial dynamics involving the fission–fusion cycle and mitophagy are the major contributing factors to better adaptation, enabling CSCs to survive and grow better under tumour micro‐environment‐associated stress. Moreover, mitophagy is balanced with mitochondrial biogenesis to maintain mitochondrial homeostasis in CSCs, which are necessary for the growth and maintenance of CSCs and regulate metabolic switching from glycolysis to oxidative phosphorylation. In this review, we discuss different aspects of mitochondrial dynamics, mitophagy, and mitochondrial homeostasis and their effects on modulating CSCs behaviour during cancer development. Moreover, the efficacy of pharmacological targeting of these cellular processes using anti‐CSC drugs in combination with currently available chemotherapeutic drugs improves the patient's survival of aggressive cancer types.

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Section: Modulation Of Mitochondrial Dynamics In Cscs: a Necessary Pr...mentioning

confidence: 99%

Dysregulation of mitophagy and mitochondrial homeostasis in cancer stem cells: Novel mechanism for anti‐cancer stem cell‐targeted cancer therapy

Praharaj

Patro

Bhutia

2021

British J Pharmacology

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Unraveling the Peculiar Features of Mitochondrial Metabolism and Dynamics in Prostate Cancer

Fontana

Anselmi

Limonta

2023

Cancers

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Prostate cancer (PCa) is the second leading cause of cancer deaths among men in Western countries. Mitochondria, the “powerhouse” of cells, undergo distinctive metabolic and structural dynamics in different types of cancer. PCa cells experience peculiar metabolic changes during their progression from normal epithelial cells to early-stage and, progressively, to late-stage cancer cells. Specifically, healthy cells display a truncated tricarboxylic acid (TCA) cycle and inefficient oxidative phosphorylation (OXPHOS) due to the high accumulation of zinc that impairs the activity of m-aconitase, the enzyme of the TCA cycle responsible for the oxidation of citrate. During the early phase of cancer development, intracellular zinc levels decrease leading to the reactivation of m-aconitase, TCA cycle and OXPHOS. PCa cells change their metabolic features again when progressing to the late stage of cancer. In particular, the Warburg effect was consistently shown to be the main metabolic feature of late-stage PCa cells. However, accumulating evidence sustains that both the TCA cycle and the OXPHOS pathway are still present and active in these cells. The androgen receptor axis as well as mutations in mitochondrial genes involved in metabolic rewiring were shown to play a key role in PCa cell metabolic reprogramming. Mitochondrial structural dynamics, such as biogenesis, fusion/fission and mitophagy, were also observed in PCa cells. In this review, we focus on the mitochondrial metabolic and structural dynamics occurring in PCa during tumor development and progression; their role as effective molecular targets for novel therapeutic strategies in PCa patients is also discussed.

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Mitochondrial fission promotes self-renewal and tumorigenic potential in prostate cancer

Cited by 2 publications

References 10 publications

Dysregulation of mitophagy and mitochondrial homeostasis in cancer stem cells: Novel mechanism for anti‐cancer stem cell‐targeted cancer therapy

Dysregulation of mitophagy and mitochondrial homeostasis in cancer stem cells: Novel mechanism for anti‐cancer stem cell‐targeted cancer therapy

Unraveling the Peculiar Features of Mitochondrial Metabolism and Dynamics in Prostate Cancer

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