Mitochondrial dynamics: Orchestrating the journey to advanced age

Biala, Agnieszka; Dhingra, Rimpy; Kirshenbaum, Lorrie A.

doi:10.1016/j.yjmcc.2015.04.015

Cited by 71 publications

(49 citation statements)

References 102 publications

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“…This phenomenon is caused by a metabolic imbalance in the body, hereby systemic demand is not met by metabolic supply, and consequently the body becomes primarily catabolic, oxidative stress increases, and ultimately a low-level inlammatory phenotype is established [18,[21][22][23][24][25][26][27][28].…”

Section: Pathophysiologymentioning

confidence: 99%

“…Multiple diseases place systemic stress demands on the body [1] that in turn leads to the inability of the body to keep pace with the demands of daily living, such as thermoregulation, aerobic respiration, glycolysis, and oxidative phosphorylation [17,22,29]. As a consequence of this baseline mismatch between the body's demand and its ability to supply, the body enters a pro-catabolic state and begins to metabolize itself for nutrient utilization [17,25].…”

Section: Pathophysiologymentioning

confidence: 99%

“…Frail patients and patients with HF consistently have a similar biochemical proile of elevated CRP and interleukin-6, which in turn promote mitochondrial dysfunction [18,22,31].…”

Section: Frailty and Heart Failurementioning

confidence: 99%

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Frailty and Cardiovascular Disease

Chainani¹,

Riehl²,

Chainani³

et al. 2017

Frailty and Sarcopenia - Onset, Development and Clinical Challenges

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Cardiovascular disease (CVD) comprises a vast spectrum of disease states ranging from hypertension (HTN) to valvular heart disease (VHD). CVD is known to be the leading cause of morbidity, mortality, and health-care expenditure throughout the world. According to the World Health Organization, coronary artery disease (CAD) and stroke, both subsets of CVD, are the world's biggest killers, accounting for a combined 15 million deaths in 2015. These diseases have remained the leading causes of death globally in the last 15 years. In 2010, CAD alone was projected to cost the U.S. $108.9 billion including the cost of health-care services, medications, and lost productivity. The presence of frailty signiicantly worsens outcomes for patients sufering from CAD. With just this one example of how frailty afects CVD, it is clear that understanding the impact of frailty upon patients alicted with the spectrum of cardiovascular disease is integral for the care of this very signiicant patient population.

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Section: Pathophysiologymentioning

confidence: 99%

Section: Pathophysiologymentioning

confidence: 99%

See 1 more Smart Citation

Frailty and Cardiovascular Disease

Chainani¹,

Riehl²,

Chainani³

et al. 2017

Frailty and Sarcopenia - Onset, Development and Clinical Challenges

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show abstract

“…ROS production throughout the cell is by no means homogeneous, and mitochondrial ROS levels are known to be a key to the function of the organelle and the cell. Mitochondrial redox signaling processes have a variety of physiological roles, including the maintenance of mitochondrial morphology (37,43), stem cell differentiation (9), and cardiac remodeling (44), while mitochondrial oxidative stress is implicated in diseases associated with aging (8,10).…”

Section: Introductionmentioning

confidence: 99%

Studies of Hematopoietic Cell Differentiation with a Ratiometric and Reversible Sensor of Mitochondrial Reactive Oxygen Species

Kaur

Jankowska

Pilgrim

et al. 2016

Antioxidants & Redox Signaling

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Aims: Chronic elevations in cellular redox state are known to result in the onset of various pathological conditions, but transient increases in reactive oxygen species (ROS)/reactive nitrogen species (RNS) are necessary for signal transduction and various physiological functions. There is a distinct lack of reversible fluorescent tools that can aid in studying and unraveling the roles of ROS/RNS in physiology and pathology by monitoring the variations in cellular ROS levels over time. In this work, we report the development of ratiometric fluorescent sensors that reversibly respond to changes in mitochondrial redox state. Results: Photophysical studies of the developed flavin-rhodamine redox sensors, flavin-rhodamine redox sensor 1 (FRR1) and flavin-rhodamine redox sensor 2 (FRR2), confirmed the reversible response of the probes upon reduction and re-oxidation over more than five cycles. The ratiometric output of FRR1 and FRR2 remained unaltered in the presence of other possible cellular interferants (metals and pH). Microscopy studies indicated clear mitochondrial localization of both probes, and FRR2 was shown to report the time-dependent increase of mitochondrial ROS levels after lipopolysaccharide stimulation in macrophages. Moreover, it was used to study the variations in mitochondrial redox state in mouse hematopoietic cells at different stages of embryonic development and maturation. Innovation: This study provides the first ratiometric and reversible probes for ROS, targeted to the mitochondria, which reveal variations in mitochondrial ROS levels at different stages of embryonic and adult blood cell production. Conclusions: Our results suggest that with their ratiometric and reversible outputs, FRR1 and FRR2 are valuable tools for the future study of oxidative stress and its implications in physiology and pathology. Antioxid. Redox Signal. 24, 667-679.

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“…Mitochondrial dysfunction leads to the accumulation of oxygen free radicals and reduced ATP production from oxidative phosphorylation, reducing cell function and energy availability, and leading to cell death (Biala et al, 2015, Lionaki et al, 2015. Mitochondrial dysfunction in ALS is therefore a potential mechanism of disrupted cellular energy production, which could have significant upstream affects on neuronal function and whole body energy balance.…”

Section: Mitochondrial Dysfunctionmentioning

confidence: 99%

Energy metabolism in amyotrophic lateral sclerosis: assessment of body composition and energy expenditure

Ioannides¹

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Mitochondrial dynamics: Orchestrating the journey to advanced age

Cited by 71 publications

References 102 publications

Frailty and Cardiovascular Disease

Frailty and Cardiovascular Disease

Studies of Hematopoietic Cell Differentiation with a Ratiometric and Reversible Sensor of Mitochondrial Reactive Oxygen Species

Energy metabolism in amyotrophic lateral sclerosis: assessment of body composition and energy expenditure

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