Mitochondrial DNA patterns in the Iberian Northern plateau: Population dynamics and substructure of the Zamora province

Álvarez, Luis; Santos, Cristina; Ramos, Ariel Delgado; Pratdesaba, Roser; Francalacci, Paolo; Aluja, María Pilar

doi:10.1002/ajpa.21252

Cited by 20 publications

(20 citation statements)

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“…If the results of consanguinity, kinship and diversity are integrated, Sanabria appears as the most isolated region, which agrees with previous work of Alvarez Edo (1984) and with our results of gene diversity using mitochondrial DNA (Alvarez et al 2010). The continuity in its settlement from the eighth to the eleventh centuries and the reduction by approximately 70% of the population over the last 50 years could partly explain its low variability.…”

Section: Diversity and Kinship Based On Surnamessupporting

confidence: 92%

Biodemographic and Genetic Structure of Zamora Province (Spain): Insights from Surname Analysis

et al. 2010

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Located in the north-western extreme of the Iberian northern plateau with the Portugal border on the west, Zamora province is one of the current divisions of the autonomous region of Castile-Leon (Spain). According to natural boundaries and historical records, the province of Zamora can be subdivided into six different regions: Aliste, Benavente, Bajo Duero, Campos-Pan, Sanabria and Sayago. The geography of the area is configured by two major rivers: the Duero that crosses the province in a westeast direction and its affluent the Esla that crosses the province in a northwest-southeast course. In this work, we analyze both surnames of 166,349 individuals from Zamora province. The main goal of this study is to explore the differential weight of historical, demographic, geographic and sociocultural factors in shaping the bio-demographic and genetic structure of this specific population. The highest value of total consanguinity based on random isonymy is observed in Sanabria, which also has the lowest values of heteronymy and the highest intra-population a priori kinship. By contrast, Sayago exhibits the highest value of heteronymy and the lowest intra-population a priori kinship. The consanguinity values observed in Zamora are, in part, related to the population structure. Notwithstanding, the values of non-random consanguinity observed in some municipalities could be associated with particular mating behaviors that favor isonymic marriages. Finally, the results of analyses indicate that the levels of micro-differentiation in the province cannot be considered high; however, some degree of substructure could be deduced. It appears that the current population structure of Zamora has been determined not only by settlement history, geographic distance and geographic boundaries, but also, by land system distribution and population size.

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Section: Diversity and Kinship Based On Surnamessupporting

confidence: 92%

Biodemographic and Genetic Structure of Zamora Province (Spain): Insights from Surname Analysis

et al. 2010

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“…48 However, the low gene and nucleotide diversities found in this region and in Northern Africa, compared with the ones found in North-Central Europe, seem to exclude Eastern Europe as a possible focus of expansion. 49,50 In the Iberian Peninsula, HV0 is a rare haplogroup, found at low frequencies in NW Spain, Zamora (4.7%), 51 a Spanish province geographically close to Braganc¸a. Because of a lack of resolution, it is not possible to differentiate haplogroup V inside HV0 in the Portuguese population.…”

Section: Sephardic Lineagesmentioning

confidence: 99%

Echoes from Sepharad: signatures on the maternal gene pool of crypto-Jewish descendants

et al. 2014

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The majority of genetic studies on Jewish populations have been focused on Ashkenazim, and genetic data from the Sephardic original source, the Iberian Peninsula, are particularly scarce. Regarding the mitochondrial genome, the available information is limited to a single Portuguese village, Belmonte, where just two different lineages (a single one corresponding to 93.3%) were found in 30 individuals. Aiming at disclosing the ancestral maternal background of the Portuguese Jewry, we enlarged the sampling to other crypto-Jewish descendants in the Braganc¸a district (NE Portugal). Fifty-seven complete mtDNA genomes were newly sequenced and -in contrast with Belmonte -a high level of diversity was found, with five haplogroups (HV0b, N1, T2b11, T2e and U2e) being putatively identified as Sephardic founding lineages. Therefore -in sharp contrast with Belmonte -these communities have managed to escape the expected inbreeding effects caused by centuries of religious repression and have kept a significant proportion of the Sephardic founder gene pool. This deeper analysis of the surviving Sephardic maternal lineages allowed a much more comprehensive and detailed perspective on the origins and survival of the Sephardic genetic heritage. In line with previously published results on Sephardic paternal lineages, our findings also show a surprising resistance to the erosion of genetic diversity in the maternal lineages.

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“…Although finding such lineages is rare outside of their proposed areas of origin, they have been reported in other populations from the Iberian Peninsula 28 and appear sporadically in European surveys in frequencies around 1% or less, as it is the case for Asturias. 70 More detailed information can be inferred by observing the raw Slatkin F ST matrix, which is in Supplementary Table 5.…”

Section: Haplogroup Composition and Diversity Of The Asturian Populationmentioning

confidence: 90%

“…27 The varied Iberian geography favors the existence of barriers and isolated populations all throughout the territory, which calls for detailed studies to account for localized historical processes. 28 These have to be paired with extensive sampling efforts to have a chance of identifying the historic and demographic processes behind the distribution of mtDNA lineages. 29 On that basis, one of the most understudied regions of the peninsula is the Principality of Asturias, which is located precisely in the western edge of the Franco-Cantabrian refuge (Figure 1).…”

Section: Introductionmentioning

confidence: 99%

Mitochondrial diversity patterns and the Magdalenian resettlement of Europe: new insights from the edge of the Franco-Cantabrian refuge

et al. 2012

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Phylogeography of the mitochondrial lineages commonly found in Western Europe can be interpreted in the light of a postglacial resettlement of the continent. The center of this proposal lies in the Franco-Cantabrian glacial refuge, located in the northern Iberian Peninsula and Southwestern France. Recently, this interpretation has been confronted by the unexpected patterns of diversity found in some European haplogroups. To shed new lights on this issue, research on Iberian populations is crucial if events behind the actual genetics of the European continent are to be untangled. In this regard, the region of Asturias has not been extensively studied, despite its convoluted history with prolonged periods of isolation. As mitochondrial DNA is a kind of data that has been commonly used in human population genetics, we conducted a thorough regional study in which we collected buccal swabs from 429 individuals with confirmed Asturian ancestry. The joint analysis of these sequences with a large continent-wide database and previously published diversity patterns allowed us to discuss a new explanation for the population dynamics inside the Franco-Cantabrian area, based on range expansion theory. This approximation to previously contradictory findings has made them compatible with most proposals about the postglacial resettlement of Western Europe.

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Mitochondrial DNA patterns in the Iberian Northern plateau: Population dynamics and substructure of the Zamora province

Cited by 20 publications

References 50 publications

Biodemographic and Genetic Structure of Zamora Province (Spain): Insights from Surname Analysis

Biodemographic and Genetic Structure of Zamora Province (Spain): Insights from Surname Analysis

Echoes from Sepharad: signatures on the maternal gene pool of crypto-Jewish descendants

Mitochondrial diversity patterns and the Magdalenian resettlement of Europe: new insights from the edge of the Franco-Cantabrian refuge

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