ABSTRACTA significant amount of reactive oxygen species (ROS) is generated during mitochondrial oxidative phosphorylation. Several studies have suggested that mtDNA may accumulate more oxidative DNA damage relative to nuclear DNA. This study used quantitative PCR to examine the formation and repair of hydrogen peroxide-induced DNA damage in a 16.2-kb mitochondrial fragment and a 17.7-kb fragment f lanking the ␤-globin gene. Simian virus 40-transformed fibroblasts treated with 200 M hydrogen peroxide for 15 or…
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