2007
DOI: 10.1080/10915810701728698
View full text |Buy / Rent full text
|
Sign up to set email alerts
|

Abstract: The bioenergetics of cardiac, liver, and kidney mitochondria after 9-day treatment regimen with benzonidazole was studied in rats. The drug was given by oral gavage to adult male Sprague-Dawley rats for 9 consecutive days (100 mg benzonidazole/kg body weight as daily dose). The assayed mitochondrial bioenergetic parameters were the state 4, state 3, respiratory control, efficiency of oxidative phosphorylation, and the activity of the mitochondrial ATP synthase. The results showed that mitochondrial parameters … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

1
4
0

Year Published

2014
2014
2014
2014

Publication Types

Select...
1

Relationship

0
1

Authors

Journals

citations
Cited by 2 publications
(5 citation statements)
references
References 22 publications
(24 reference statements)
1
4
0
Order By: Relevance
“…The results of the current study, together with the previously reported data, 10 indicate that the liver might be a target of potentially toxic effects of benznidazole. This suggestion supports previously reported clinical observations, in which this drug, given repeatedly, results in liver toxicity.…”
Section: Discussionsupporting
confidence: 84%
See 4 more Smart Citations
“…The results of the current study, together with the previously reported data, 10 indicate that the liver might be a target of potentially toxic effects of benznidazole. This suggestion supports previously reported clinical observations, in which this drug, given repeatedly, results in liver toxicity.…”
Section: Discussionsupporting
confidence: 84%
“…On the other hand, the decrease in RC (Figure 1(c) and (f)) resulting from the state 4 respiration increase (Figure 1(a) and (d)) indicates that mitochondria in liver homogenates were partially uncoupled, in contrast to the previously reported 10 unchanged functional state of isolated and washed liver mitochondria after an identical treatment of rats with benznidazole. All these facts indicate that when treated with benznidazole, the liver might generate some mitochondrial uncoupling factor(s) that are removed during the procedure of mitochondrial isolation.…”
Section: Discussionmentioning
confidence: 57%
See 3 more Smart Citations