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Cited by 1 publication
(2 citation statements)
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References 7 publications
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“…The nodes producing the normalized expressions of critical markers and stress response activities are shown as functional clusters in Figure 1A. This network was constructed within our simulation interface in part by integrating the on-off behavior of Boolean network modeling, however, the nodes were designed using system-dynamics techniques (ODEbased) of primarily saturable Hill functions, which we have previously modeled for nuclear receptors (Hoffman et al, 2018). This allowed us to produce normalized response fractions for each of the molecular markers involved in the full signature of interest.…”
Section: Simulation Design and The Molecular Signaturementioning
confidence: 99%
See 1 more Smart Citation
“…The nodes producing the normalized expressions of critical markers and stress response activities are shown as functional clusters in Figure 1A. This network was constructed within our simulation interface in part by integrating the on-off behavior of Boolean network modeling, however, the nodes were designed using system-dynamics techniques (ODEbased) of primarily saturable Hill functions, which we have previously modeled for nuclear receptors (Hoffman et al, 2018). This allowed us to produce normalized response fractions for each of the molecular markers involved in the full signature of interest.…”
Section: Simulation Design and The Molecular Signaturementioning
confidence: 99%
“…It is well understood that mitochondria play a critical role in the aging process (Hekimi et al, 2011;Wang and Hekimi, 2015;Labbadia et al, 2017;Hoffman et al, 2017Hoffman et al, , 2018. Because of this, energetically demanding cells (e.g., myocytes, neurons) that rely heavily on the integrity of their abundant mitochondrial populations are most affected by age.…”
Section: Introductionmentioning
confidence: 99%