2014
DOI: 10.18632/aging.100654
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Abstract: Mitochondria have been considered for long time as important determinants of cell aging because of their role in the production of reactive oxygen species. In this study we investigated the impact of mitochondrial metabolism and biology as determinants of successful aging in primary cultures of fibroblasts isolated from the skin of long living individuals (LLI) (about 100 years old) compared with those from young (about 27 years old) and old (about 75 years old) subjects. We observed that fibroblasts from LLI … Show more

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Cited by 61 publications
(39 citation statements)
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References 51 publications
(61 reference statements)
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“…Third, some of the autophagy-lysosomal DEGs are also up-regulated in F1s who have a similar age distribution with F1SPs, indicative of a partially heritable nature of enhanced autophagy-lysosomal functions. Fourth, the long-lived individuals (about 100 yr old) have higher autophagic signal in their skin fibroblasts than either the old (about 75 yr old) or the young (about 27 yr old) subjects, while there is no significant difference between the old and the young groups (Sgarbi et al 2014). Finally, and most importantly, an enhanced autophagy-lysosomal function has been shown to extend the life span in model organisms, as revealed by two recent studies in mouse, with one revealing that activating the autophagy-lysosome pathway improves the function of quiescent neural stem cells in old mice (Leeman et al 2018), while the other showed that increasing the autophagic function via disrupting the beclin 1-BCL2 complex can improve the health span and promote longevity in mice (Fernandez et al 2018).…”
Section: Discussionmentioning
confidence: 96%
“…Third, some of the autophagy-lysosomal DEGs are also up-regulated in F1s who have a similar age distribution with F1SPs, indicative of a partially heritable nature of enhanced autophagy-lysosomal functions. Fourth, the long-lived individuals (about 100 yr old) have higher autophagic signal in their skin fibroblasts than either the old (about 75 yr old) or the young (about 27 yr old) subjects, while there is no significant difference between the old and the young groups (Sgarbi et al 2014). Finally, and most importantly, an enhanced autophagy-lysosomal function has been shown to extend the life span in model organisms, as revealed by two recent studies in mouse, with one revealing that activating the autophagy-lysosome pathway improves the function of quiescent neural stem cells in old mice (Leeman et al 2018), while the other showed that increasing the autophagic function via disrupting the beclin 1-BCL2 complex can improve the health span and promote longevity in mice (Fernandez et al 2018).…”
Section: Discussionmentioning
confidence: 96%
“…On the other hand, low levels of ROS are well known to trigger an adaptive hormetic response, generating a stress resistant reaction and increased cell longevity [34]. Successful aging has also been related to functional mitochondrial dynamics, where centenarians were shown to have high rates of mitochondrial autophagy [35]. At the molecular level, mitochondrial protein turnover has been associated with extension of longevity by activating the mitochondrial unfolded protein response (UPR mt ).…”
Section: Discussionmentioning
confidence: 99%
“…Two major questions arise from our work: how NMRs have evolved their particular liver metabolism, and how does this contribute to the extreme longevity of these animals? Multiple studies have previously linked the composition of the mitochondrial respiratory chain to lifespan extension in multiple species [31]: altered composition of the respiratory chain has been show to induce a hormetic response that can extend lifespan in C.elegans [39]; mild inhibition of complex I leads to increased lifespan in the short-lived fish N. furzeri [40]; low abundance of the matrix arm of complex I predicts longevity in mice [41]; fibroblasts isolated from long lived individuals including centenarians show altered mitochondrial activity with lower complex I driven ATP synthesis [42].…”
Section: Discussionmentioning
confidence: 99%