Mitochondria-derived cell-to-cell communication

Dache, Zahra Al Amir; Thierry, Alain R.

doi:10.1016/j.celrep.2023.112728

Cited by 27 publications

(12 citation statements)

References 129 publications

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“…We also found that cir-nDNA levels in HI was not associated with NETs markers. These results confirm our previous work on the origin of cir-nDNA in cancer patients and HIs [ 21 ]. To date, this is the first study to show that elevated cir-nDNA levels may be derived from NETs in the perioperative period.…”

Section: Discussionsupporting

confidence: 92%

“…In 2015, our own team was among the first to postulate that cir-nDNA found in cancer patient plasma may significantly originate from NETs [ 3 ]. We subsequently observed that the concentrations of cir-nDNA in newly diagnosed mCRC patients were positively associated with NETs protein markers (NE and MPO) [ 21 ]. This work showed that a proportion of cirDNA in cancer patients may derive from immune cells, in particular neutrophils.…”

Section: Discussionmentioning

confidence: 99%

“…For these reasons, cirDNA dynamics in the immediate perioperative period have until now been understudied if not neglected. This study focused on the perioperative level of total nuclear cir-nDNA and on circulating DNA of mitochondrial origin (cir-mtDNA), and aims at evaluating the influence of neutrophil extracellular traps (NETs) degradation recently found to be associated with cirDNA release [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

“…It has also been shown that anticoagulant drugs inhibit the formation of NETs [ 39 ]. We ourselves have shown that cir-nDNA concentrations in newly-diagnosed metastatic colorectal cancer (mCRC) patients are positively associated with NETs protein markers (NE and MPO) [ 21 ]. Similarly, we have demonstrated that cirDNA can derive from chromatin or NETs [ 40 ].…”

Section: Introductionmentioning

confidence: 99%

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Association of the immediate perioperative dynamics of circulating DNA levels and neutrophil extracellular traps formation in cancer patients

Kudriavtsev,

Pastor,

Mirandola

et al. 2024

Precision Clinical Medicine

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Objectives Elevated circulating DNA (cirDNA) concentrations were found to be associated with trauma or tissue damage which suggests involvement of inflammation or cell death in post-operative cirDNA release. We carried out the first prospective, multicenter study of the dynamics of cirDNA and neutrophil extracellular traps (NETs) markers during the perioperative period from 24 hours before surgery up to 72 hours after curative surgery in cancer patients. Methods We examined the plasma levels of two NETs protein markers (myeloperoxidase (MPO) and neutrophil elastase (NE)), as well as levels of cirDNA of nuclear (cir-nDNA) and mitochondrial (cir-mtDNA) origins in 29 patients colon, prostate and breast cancer and in 114 healthy individuals (HI). Results The synergistic analytical information provided by these markers revealed that: (i) NETs formation contributes to post-surgery conditions; (ii) post-surgery cir-nDNA levels were highly associated with NE and MPO in colon cancer (r=0.60 (p<0.001) and r=0.53 (p<0.01), respectively), but not in prostate and breast cancer; (iii) each tumor type shows a specific pattern of cir-nDNA and NETs marker dynamics, but overall the pre- and post-surgery median values of cir-nDNA, NE, and MPO were significantly higher in cancer patients than in HI. Conclusion Taken as a whole, our work reveals the association of NETs formation with the elevated cir-nDNA release during a cancer patient's perioperative period, depending on surgical procedure or cancer type. By contrast, cir-mtDNA is poorly associated with NETs formation in the studied perioperative period, which would appear to indicate a different mechanism of release or suggest mitochondria dysfunction.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Association of the immediate perioperative dynamics of circulating DNA levels and neutrophil extracellular traps formation in cancer patients

Kudriavtsev,

Pastor,

Mirandola

et al. 2024

Precision Clinical Medicine

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“…Some research suggests that tumor cells tend to favor glycolysis for energy production over oxidative phosphorylation. This shift in metabolic pathways, known as the " Warburg effect," could be influenced by changes in mitochondrial function 6 , 36 . In this study, we analyzed GSE13507 datasets and identified 752 DE-MRGs in BC patients.…”

Section: Discussionmentioning

confidence: 99%

Machine-learning prediction of a novel diagnostic model using mitochondria-related genes for patients with bladder cancer

Li,

Wang,

Wang

2024

Sci Rep

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Bladder cancer (BC) is the ninth most-common cancer worldwide and it is associated with high morbidity and mortality. Mitochondrial Dysfunction is involved in the progression of BC. This study aimed to developed a novel diagnostic model based on mitochondria-related genes (MRGs) for BC patients using Machine Learning. In this study, we analyzed GSE13507 datasets and identified 752 DE-MRGs in BC specimens. Functional enrichment analysis uncovered the significant roles of 752 DE-MRGs in key processes such as cellular and organ development, as well as gene regulation. The analysis revealed the crucial functions of these genes in transcriptional regulation and protein-DNA interactions. Then, we performed LASSO and SVM-RFE, and identified four critical diagnostic genes including GLRX2, NMT1, OXSM and TRAF3IP3. Based on the above four genes, we developed a novel diagnostic model whose diagnostic value was confirmed in GSE13507, GSE3167 and GSE37816 datasets. Moreover, we reported the expressing pattern of GLRX2, NMT1, OXSM and TRAF3IP3 in BC samples. Immune cell infiltration analysis revealed that the four genes were associated with several immune cells. Finally, we performed RT-PCR and confirmed NMT1 was highly expressed in BC cells. Functional experiments revealed that knockdown of NMT1 suppressed the proliferation of BC cells. Overall, we have formulated a diagnostic potential that offered a comprehensive framework for delving into the underlying mechanisms of BC. Before proceeding with clinical implementation, it is essential to undertake further investigative efforts to validate its diagnostic effectiveness in BC patients.

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Inflammation‐, immunothrombosis,‐ and autoimmune‐feedback loops may lead to persistent neutrophil self‐stimulation in long COVID

Thierry,

Salmon

2024

Journal of Medical Virology

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Understanding the pathophysiology of long COVID is one of the most intriguing challenges confronting contemporary medicine. Despite observations recently made in the relevant molecular, cellular, and physiological domains, it is still difficult to say whether the post‐acute sequelae of COVID‐19 directly correspond to the consequences of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection. This work hypothesizes that neutrophils and neutrophil extracellular traps (NETs) production are at the interconnection of three positive feedback loops which are initiated in the acute phase of SARS‐CoV‐2 infection, and which involve inflammation, immunothrombosis, and autoimmunity. This phenomenon could be favored by the fact that SARS‐CoV‐2 may directly bind and penetrate neutrophils. The ensuing strong neutrophil stimulation leads to a progressive amplification of an exacerbated and uncontrolled NETs production, potentially persisting for months beyond the acute phase of infection. This continuous self‐stimulation of neutrophils leads, in turn, to systemic inflammation, micro‐thromboses, and the production of autoantibodies, whose significant consequences include the persistence of endothelial and multiorgan damage, and vascular complications.

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Mitochondria-derived cell-to-cell communication

Cited by 27 publications

References 129 publications

Association of the immediate perioperative dynamics of circulating DNA levels and neutrophil extracellular traps formation in cancer patients

Association of the immediate perioperative dynamics of circulating DNA levels and neutrophil extracellular traps formation in cancer patients

Machine-learning prediction of a novel diagnostic model using mitochondria-related genes for patients with bladder cancer

Inflammation‐, immunothrombosis,‐ and autoimmune‐feedback loops may lead to persistent neutrophil self‐stimulation in long COVID

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