Mitigation of human iris angiogenesis through uPAR/LRP‐1 interaction antagonism in an organotypic ex vivo model
Noemi Anna Pesce,
Flavia Plastino,
Claudia Reyes‐Goya
et al.
Abstract:Rubeosis Iridis (RI) is characterized by an increase in neovascularization and inflammation factors in the iris. During angiogenesis, the urokinase plasminogen activator (uPA) and its receptor (uPAR) play a pivotal role in extracellular matrix remodeling, where uPAR regulates endothelial cell migration and proliferation through assembly with transmembrane receptors. Here, in the context of hypoxia‐induced angiogenesis, the uPA/uPAR system blockage was investigated by using UPARANT in a novel ex vivo human iris… Show more
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