Mismatch negativity potentials and cognitive impairment in schizophrenia

Baldeweg, Torsten; Klugman, Anthony; Gruzelier, John; Hirsch, S.R.

doi:10.1016/j.schres.2003.09.009

Cited by 273 publications

(316 citation statements)

References 57 publications

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“…Electroencephalographic (EEG) activity was measured during an auditory 'roving' oddball paradigm (Baldeweg et al, 2004;Boly et al, 2011;Garrido et al, 2008;Haenschel et al, 2005), originally developed by Cowan et al (1993). Acoustic stimuli were generated by the E-prime software (Schneider et al, 2002), and applied binaurally through headphones (TDH-39-P; Maico, Minneapolis, MN).…”

Section: Auditory Test Paradigm (Mmn)mentioning

confidence: 99%

Mismatch Negativity Encoding of Prediction Errors Predicts S-ketamine-Induced Cognitive Impairments

Schmidt

Bachmann

Kometer

et al. 2011

Neuropsychopharmacol

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Psychotomimetics like the N-methyl-D-aspartate receptor (NMDAR) antagonist ketamine and the 5-hydroxytryptamine2A receptor (5-HT 2A R) agonist psilocybin induce psychotic symptoms in healthy volunteers that resemble those of schizophrenia. Recent theories of psychosis posit that aberrant encoding of prediction errors (PE) may underlie the expression of psychotic symptoms. This study used a roving mismatch negativity (MMN) paradigm to investigate whether the encoding of PE is affected by pharmacological manipulation of NMDAR or 5-HT 2A R, and whether the encoding of PE under placebo can be used to predict drug-induced symptoms. Using a doubleblind within-subject placebo-controlled design, S-ketamine and psilocybin, respectively, were administrated to two groups of healthy subjects. Psychological alterations were assessed using a revised version of the Altered States of Consciousness (ASC-R) questionnaire. As an index of PE, we computed changes in MMN amplitudes as a function of the number of preceding standards (MMN memory trace effect) during a roving paradigm. S-ketamine, but not psilocybin, disrupted PE processing as expressed by a frontally disrupted MMN memory trace effect. Although both drugs produced positive-like symptoms, the extent of PE processing under placebo only correlated significantly with the severity of cognitive impairments induced by S-ketamine. Our results suggest that the NMDAR, but not the 5-HT 2A R system, is implicated in PE processing during the MMN paradigm, and that aberrant PE signaling may contribute to the formation of cognitive impairments. The assessment of the MMN memory trace in schizophrenia may allow detecting early phases of the illness and might also serve to assess the efficacy of novel pharmacological treatments, in particular of cognitive impairments.

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Section: Auditory Test Paradigm (Mmn)mentioning

confidence: 99%

Mismatch Negativity Encoding of Prediction Errors Predicts S-ketamine-Induced Cognitive Impairments

Schmidt

Bachmann

Kometer

et al. 2011

Neuropsychopharmacol

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“…Deficits in early auditory sensory processing, including N1, MMN, and P300, have been shown using ERP in schizophrenic subjects (Baldeweg et al, 2004;Kasai et al, 2002;Salisbury et al, 1998;Javitt et al, 2000;Javitt et al, 1995;Elvevag et al, 2004), in prodromal subjects (Brockhaus-Dumke et al, 2005), and in SPD subjects (Salisbury et al, 1996;Niznikiewicz et al, 2000;Liu et al, 2007). Moreover, progressive changes in schizophrenic subjects can be indexed using a MMN paradigm in the ERP environment (Salisbury et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, progressive changes in schizophrenic subjects can be indexed using a MMN paradigm in the ERP environment (Salisbury et al, 2007). Indeed, ERP has certain advantages in testing auditory sensory processing in that tones can be played in sound-proof laboratories with little to no extraneous noise, experimental design allows for a large number of deviants, greater than 160 in most studies (Shelley et al, 1991;Javitt et al, 1995;Umbricht et al, 1998;Michie et al, 2000;Baldeweg et al, 2004;Brockhaus-Dumke et al, 2005) (exception, Kirino and Inoue, 1999) and allows for precise time recordings on the order of milliseconds at the expense of poor spatial resolution.…”

Section: Discussionmentioning

confidence: 99%

“…Stimuli used across studies have varied with differences between standard and deviant pitches as small as 24 Hz (1000-1024 Hz) (Javitt et al, 1995) to as large as 1000 Hz (1000-2000 Hz) (Kirino and Inoue, 1999) and differences in duration as small as 25 ms (25-50 ms) (Baldeweg et al, 2004). Nonetheless, the presence of the MMN-like deflection in both conditions suggests that these experimental parameters engage the early auditory sensory processing stream.…”

Section: Discussionmentioning

confidence: 99%

“…Auditory sensory processing has been found to be impaired in schizophrenia (Salisbury et al, 1998;Javitt et al, 2000) and correlate with clinical features, particularly negative symptoms (Javitt et al, 2000), (Kasai et al, 2002) (Leitman et al, 2005) and cognitive impairment (Baldeweg et al, 2004). Abnormalities in the superior temporal gyrus (STG) have been implicated in the processing of pure tones, a fundamental element of complex sounds and language, using fMRI (Wible et al, 2001) and event-related potentials (Salisbury et al, 1998).…”

Section: Introductionmentioning

confidence: 99%

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Auditory processing abnormalities in schizotypal personality disorder: An fMRI experiment using tones of deviant pitch and duration

Dickey

Mórocz

Niznikiewicz

et al. 2008

Schizophrenia Research

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Background-One of the cardinal features of schizotypal personality disorder (SPD) is language abnormalities. The focus of this study was to determine whether or not there are also processing abnormalities of pure tones differing in pitch and duration in SPD.Methods-Thirteen neuroleptic-naïve male subjects met full criteria for SPD and were groupmatched on age and parental socioeconomic status to 13 comparison subjects. Verbal learning was measured with the California Verbal Learning Test. Heschl's gyrus volumes were measured using structural MRI. Whole-brain fMRI activation patterns in an auditory task of listening to tones including pitch and duration deviants were compared between SPD and control subjects. In a Contributors Dickey: designed the study, collected the fMRI data, analyzed the clinical and fMRI data, and wrote the manuscript. Morocz: analyzed the fMRI data. Niznikiewicz: collected and analyzed the ERP data, and contributed to the manuscript. Voglmaier: collected and analyzed CVLT data, and performed SCID interview. Dreusicke: analyzed the fMRI data. Toner: aided in fMRI data collection. Yoo: aided in initial fMRI data collection. Khan: aided in final fMRI data presentation. Shenton: reviewed the manuscript. McCarley: reviewed the manuscript. Conflict of interestAll authors declare that they have no conflict of interest. Results-In the region of the STG, SPD subjects demonstrated more activation to pitch deviants bilaterally (p<0.001); and to duration deviants in the left hemisphere (p=0.005) (two-sample t). SPD subjects also showed more bilateral parietal cortex activation to duration deviants. In no region did comparison subjects activate more than SPD subjects in either experiment. Exploratory correlations for SPD subjects suggest a relationship between peak activation on the right for deviant tones in the pitch experiment with odd speech and impaired verbal learning. There was no difference between groups on Heschl's gyrus volume. NIH Public AccessConclusions-These data suggest that SPD subjects have inefficient or hyper-responsive processing of pure tones both in terms of pitch and duration deviance that is not attributable to smaller Heschl's gyrus volumes. Finally, these auditory processing abnormalities may have significance for the odd speech heard in some SPD subjects and downstream language and verbal learning deficits.

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Contribution of Impaired Early-Stage Visual Processing to Working Memory Dysfunction in Adolescents With Schizophrenia

Haenschel

Bittner²,

Haertling³

et al. 2007

Arch Gen Psychiatry

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139

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Mismatch negativity potentials and cognitive impairment in schizophrenia

Cited by 273 publications

References 57 publications

Mismatch Negativity Encoding of Prediction Errors Predicts S-ketamine-Induced Cognitive Impairments

Mismatch Negativity Encoding of Prediction Errors Predicts S-ketamine-Induced Cognitive Impairments

Auditory processing abnormalities in schizotypal personality disorder: An fMRI experiment using tones of deviant pitch and duration

Contribution of Impaired Early-Stage Visual Processing to Working Memory Dysfunction in Adolescents With Schizophrenia

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