Mirror movements in Parkinson's disease: An under-appreciated clinical sign

Chatterjee, Payel; Banerjee, Rebecca; Choudhury, Supriyo; Mondal, Banashree; Kulsum, Marium Umme; Chatterjee, Koustav; Kumar, Hrishikesh

doi:10.1016/j.jns.2016.05.026

Cited by 7 publications

(7 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The clinical features include bradykinesia, rigidity, and/or resting tremor. MMs have been previously reported to occur in 29–95.7% of PD patients ( 12 , 13 ). The differences in MM prevalence among studies were mainly related to the symptom severity and assessment methods.…”

Section: Clinical Characteristics Of Mms In Different Acquired Neurological Diseasesmentioning

confidence: 99%

“…MM severity was also correlated with the "on" and "off " states such that mirroring was slightly greater when the patients were off medication (21). However, Chatterjee et al found that MM scores were higher for lower limb tasks in the on phase (12). By applying surface EMG in PD patients without overt MMs, Cincotta found that MA during intended unimanual movements was significantly enhanced compared with age-matched or young healthy volunteers (21).…”

Section: Clinical Characteristicmentioning

confidence: 99%

“…Ipsilateral corticospinal tract reorganization is the most accepted theory ( 9 ). MMs may also emerge later in life along with neuropsychiatric disorders, such as those associated with lesions in the pyramidal system, that is, stroke ( 10 ) and amyotrophic lateral sclerosis (ALS) ( 11 ), or extrapyramidal diseases such as Parkinson's disease (PD) ( 12 , 13 ) and essential tremor (ET) ( 14 ). As the result of evolutionary advances in instruments and detection methods, such as surface electromyography (EMG) techniques, transcranial magnetic stimulation (TMS), and functional brain imaging, subtle mirroring or subclinical MMs have been fully revealed and the underlying mechanisms of MMs have been studied comprehensively ( 2 ).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Mirror Movements in Acquired Neurological Disorders: A Mini-Review

et al. 2021

View full text Add to dashboard Cite

Mirror movements (MMs) are specifically defined as involuntary movements occurring on one side of homologous muscles when performing unilateral movements with the contralateral limb. MMs have been considered a kind of soft neurological signs, and the persistence or reappearance of MMs in adults is usually pathologic. In addition to some congenital syndrome, MMs have been also described in age-related neurological diseases including pyramidal system diseases (e.g., stroke, amyotrophic lateral sclerosis) and extrapyramidal disorders (e.g., Parkinson's disease, essential tremor). With the advances in instrumentation and detection means, subtle or subclinical MMs have been deeply studied. Furthermore, the underlying mechanism is also being further elucidated. In this mini-review, we firstly discuss the MM examination means, and then review the literature regarding MMs in individuals with acquired neurological disorders, in order to further understand the pathogenesis of MMs.

show abstract

Section: Clinical Characteristics Of Mms In Different Acquired Neurological Diseasesmentioning

confidence: 99%

Section: Clinical Characteristicmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Mirror Movements in Acquired Neurological Disorders: A Mini-Review

et al. 2021

View full text Add to dashboard Cite

show abstract

“…It can be noted that mirror movements have been considered either physiological, presenting in healthy children and can be elicited in adults under conditions of intense physical activity, movements involving large force generation, and proximal muscle use (8,9); or pathological when mirror movements persist in the adult with age-related neurological diseases (e.g., stroke, amyotrophic lateral sclerosis, Parkinson's disease, etc.) (10)(11)(12).…”

Section: Introductionmentioning

confidence: 99%

We Move or Are We Moved? Unpicking the Origins of Voluntary Movements to Better Understand Semivoluntary Movements

Virameteekul

Bhidayasiri²

2022

Front. Neurol.

View full text Add to dashboard Cite

The capacity for voluntary control is seen as essential to human movements; the sense that one intended to move (willing) and those actions were self-generated (self-agency) gives the sense of voluntariness and of being in control. While the mechanisms underlying voluntary movement have long been unclear, recent neuroscientific tools have identified networks of different brain areas, namely, the prefrontal cortex, supplementary motor area, and parietal cortex, that underlie voluntary action. Dysfunction in these brain areas can result in different forms of semivoluntary movement as the borderland of voluntary and involuntary movement where a person may experience a disordered sense of will or agency, and thus the movement is experienced as unexpected and involuntary, for an otherwise voluntary-appearing movement. Tics, functional movement disorders, stereotypies, perseveration, compulsions, utilization behaviors, and motor mannerism have been described elsewhere in the context of psychoses, and are often mistaken for each other. Yet, they reflect an impairment of prefrontal cortices and related circuits rather than simple motor systems, which results in the absence of subjective recognition of the movements, in contrast to other neurological movement disorders where principal abnormalities are located within the basal ganglia and its connections. Therefore, their recognition is clinically important since they are usually associated with neurodevelopmental and neurodegenerative disorders. In this review, we first defined a conceptual framework, from both a neuroanatomical and a neurophysiological point of view, for the generation of voluntary movement. We then examined the evidence linking dysfunctions in different motor pathways to each type of movement disorder. We looked at common semivoluntary movement disorders providing an overview, where possible, of their phenomenology and brain network abnormalities for each condition. We also emphasized important clinical feature similarities and differences to increase recognition of each condition in practice.

show abstract

“…Mirror movements, where voluntary movements of one limb is accompanied by corresponding involuntary movements of the opposite limb, have been reported in several movement disorders and have been described as a result of inter-hemispheric cross-talk or motor overflow [11, 12]. In accordance, mirror movements have been found to be highly present and persistent in persons with idiopathic PD [13] and to be more pronounced than in healthy peers [14]. Furthermore, persons with PD tend to unintentionally synchronize asynchronic alternating bimanual movements at a lower movement frequency than healthy persons do [15, 16].…”

Section: Introductionmentioning

confidence: 99%

The effect of 8 weeks of treatment with transcranial pulsed electromagnetic fields on hand tremor and inter-hand coherence in persons with Parkinson’s disease

Malling

Morberg

Wermuth

et al. 2019

J NeuroEngineering Rehabil

View full text Add to dashboard Cite

BackgroundParkinson’s disease (PD) tremor comprises asymmetric rest and postural tremor with unilateral onset. Tremor intensity can be amplified by stress and reduced by attention, and the medical treatment is complex. Mirror movements and unintentional synchronization of bimanual movements, possibly caused by insufficient inhibition of inter-hemispheric crosstalk, have been reported in PD, indicating a lag of lateralization.Potential neuroprotective effects of pulsed electromagnetic fields (PEMF) have been reported in-vitro and in rodents, as have influences of PEMF on human tremor.The aim was to investigate the effect of 8 weeks daily transcranial PEMF treatment (T-PEMF) of persons with PD on rest and postural hand tremor characteristics and on inter-hand coherence.MethodsHand accelerations of 50 PD participants with uni- or bilateral tremor participating in a clinical trial were analysed. A rest and postural tremor task performed during serial subtraction was assessed before and after 8 weeks of T-PEMF (30 min/day, 50 Hz, ±50 V, 3 ms squared pulses) or placebo treatment (sham stimulation 30 min/day). Forty matched healthy persons (no treatment) were included as reference. Intensity and inter-hand coherence related measures were extracted.ResultsThe T-PEMF treatment decreased the inter-hand coherence in the PD group with unilateral postural tremor. The PD group with unilateral postural tremor was less clinically affected by the disease than the PD group with bilateral postural tremor. However, no differences between T-PEMF and placebo treatment on either intensity related or coherence related measures were found when all persons with PD were included in the analyses. The peak power decreased and the tremor intensity tended to decrease in both treatment groups.ConclusionsEight weeks of T-PEMF treatment decreased inter-hand coherence in the PD group with unilateral postural tremor, while no effects of T-PEMF treatment were found for the entire PD group. The unilateral postural tremor group was less clinically affected than the bilateral postural tremor group, suggesting that early treatment initiation may be beneficial. In theory, a reduced inter-hand coherence could result from a neuronal treatment response increasing inter-hemispheric inhibition. However, this requires further studies to determine. Studies of even longer treatment periods would be of interest.Trial registrationClinicalTrials.gov, NCT02125032. Registered 29 April 2014, https://clinicaltrials.gov/ct2/show/NCT02125032?term=NCT02125032&rank=1Electronic supplementary materialThe online version of this article (10.1186/s12984-019-0491-2) contains supplementary material, which is available to authorized users.

show abstract

Mirror movements in Parkinson's disease: An under-appreciated clinical sign

Cited by 7 publications

References 16 publications

Mirror Movements in Acquired Neurological Disorders: A Mini-Review

Mirror Movements in Acquired Neurological Disorders: A Mini-Review

We Move or Are We Moved? Unpicking the Origins of Voluntary Movements to Better Understand Semivoluntary Movements

The effect of 8 weeks of treatment with transcranial pulsed electromagnetic fields on hand tremor and inter-hand coherence in persons with Parkinson’s disease

Contact Info

Product

Resources

About