miRNA Modulation of Insect Virus Replication

Monsanto-Hearne, Verna; Johnson, Karyn N.

doi:10.21775/cimb.034.061

Cited by 7 publications

(6 citation statements)

References 44 publications

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“…Within this complex relationship between host and parasite, molecular dialogues occur that aim to either terminate the infective process or weaken the host’s defense mechanisms to facilitate successful invasion. RNAi mechanisms play a significant role in these interplays within eukaryotes [ 41 , 42 ]. As a result, the presence of cellular miRNA genes that can impact viral processes, as well as viral miRNA genes that regulate their own expression cascades to counteract the host, emerge as notable features in viral infections.…”

Section: Baculovirus-encoded Mirnasmentioning

confidence: 99%

A Comprehensive Study of MicroRNA in Baculoviruses

Motta,

Cerrudo,

Belaich

2024

IJMS

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Baculoviruses are viral pathogens that infect different species of Lepidoptera, Diptera, and Hymenoptera, with a global distribution. Due to their biological characteristics and the biotechnological applications derived from these entities, the Baculoviridae family is an important subject of study and manipulation in the natural sciences. With the advent of RNA interference mechanisms, the presence of baculoviral genes that do not code for proteins but instead generate transcripts similar to microRNAs (miRNAs) has been described. These miRNAs are functionally associated with the regulation of gene expression, both in viral and host sequences. This article provides a comprehensive review of miRNA biogenesis, function, and characterization in general, with a specific focus on those identified in baculoviruses. Furthermore, it delves into the specific roles of baculoviral miRNAs in regulating viral and host genes and presents structural and thermodynamic stability studies that are useful for detecting shared characteristics with predictive utility. This review aims to expand our understanding of the baculoviral miRNAome, contributing to improvements in the production of baculovirus-based biopesticides, management of resistance phenomena in pests, enhancement of recombinant protein production systems, and development of diverse and improved BacMam vectors to meet biomedical demands.

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Section: Baculovirus-encoded Mirnasmentioning

confidence: 99%

A Comprehensive Study of MicroRNA in Baculoviruses

Motta,

Cerrudo,

Belaich

2024

IJMS

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“…There are studies that show that miRNAs are not only regulators of biological processes, but can also participate in parasite-host interaction processes 9,27 . In insects affected by viruses, it has been observed that viruses are capable of releasing miRNAs that can regulate the expression of their host genes in order to successfully establish the infection 28 . For C. rogercresseyi, several miRNAs expressed during the different stages of development have been characterized 29,30 .…”

Section: Background and Summarymentioning

confidence: 99%

Chromosome-scale genome assembly of the sea louse Caligus rogercresseyi by SMRT sequencing and Hi-C analysis

et al. 2021

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Caligus rogercresseyi, commonly known as sea louse, is an ectoparasite copepod that impacts the salmon aquaculture in Chile, causing losses of hundreds of million dollars per year. In this study, we report a chromosome-scale assembly of the sea louse (C. rogercresseyi) genome based on single-molecule real-time sequencing (SMRT) and proximity ligation (Hi-C) analysis. Coding RNAs and non-coding RNAs, and specifically long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) were identified through whole transcriptome sequencing from different life stages. A total of 23,686 protein-coding genes and 12,558 non-coding RNAs were annotated. In addition, 6,308 lncRNAs and 5,774 miRNAs were found to be transcriptionally active from larvae to adult stages. Taken together, this genomic resource for C. rogercresseyi represents a valuable tool to develop sustainable control strategies in the salmon aquaculture industry.

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“…Host noncoding RNAs ( ncRNAs ), including long noncoding RNAs ( lncRNAs ) and miRNAs, play important roles in multiple biological processes during viral infection, including apoptosis, host metabolism, immunity and inflammatory responses, or viral life-cycle phases ( Liu and Ding, 2017 ; Trobaugh and Klimstra, 2017 ; Lu et al, 2020 ; Monsanto-Hearne and Johnson, 2020 ). For examples, LncRNA MEG3 ameliorates respiratory syncytial virus infection by suppressing TLR4 signaling ( Tao et al, 2018 ); LINC00173 TSV1 and TSV2 are upregulated during HIV-1 infection and contribute to the regulation of viral transcription ( Chang et al, 2011 ; Mohammadi et al, 2013 ; Postler et al, 2017 ; Trypsteen et al, 2016 ); miR-21-3p regulates influenza A virus replication by targeting histone deacetylase-8 ( Xia et al, 2018 ); miR-30 inhibits influenza virus infection by suppressing the expression of SOCS1, SOCS3, and NEDD4 ( Lin et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Whole-transcriptome sequencing revealed the role of noncoding RNAs in susceptibility and resistance of Pekin ducks to DHAV-3

Ding,

Zhao,

Liu

et al. 2024

Poultry Science

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miRNA Modulation of Insect Virus Replication

Cited by 7 publications

References 44 publications

A Comprehensive Study of MicroRNA in Baculoviruses

A Comprehensive Study of MicroRNA in Baculoviruses

Chromosome-scale genome assembly of the sea louse Caligus rogercresseyi by SMRT sequencing and Hi-C analysis

Whole-transcriptome sequencing revealed the role of noncoding RNAs in susceptibility and resistance of Pekin ducks to DHAV-3

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