Proc Natl Acad Sci USA volume 115, issue 5, P1069-1074 2018 DOI: 10.1073/pnas.1719036115 View Full Text
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Rasmus Møller, Toni M. Schwarz, Vanessa M. Noriega, Maryline Panis, David Sachs, Domenico Tortorella, Benjamin R. tenOever

Abstract: Human cytomegalovirus (HCMV) impacts more than one-half of the human population owing to its capacity to manipulate the cell and create latent reservoirs in the host. Despite an extensive understanding of HCMV biology during acute infection in fibroblasts, the molecular basis for latency in myeloid cells remains incomplete. This knowledge gap is due largely to the fact that the existing genetic systems require virus rescue in fibroblasts, precluding the study of genes that are essential during acute infection,…

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