miRNA-223 at the crossroads of inflammation and cancer

Jeffries, Jacob; Zhou, Wenqing; Hsu, Alan Y.; Deng, Qing

doi:10.1016/j.canlet.2019.02.051

Cited by 74 publications

(57 citation statements)

References 76 publications

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“…It is known that miRNAs play a critical role in tumor progression by regulating the gene expression at the posttranscriptional level. Several miRNAs, including miR‐22, miR‐223, and miR‐155‐3p, have been implicated in human cancers (Jeffries, Zhou, Hsu, & Deng, ; Xu. Li et al, , Xu, Yao et al, ; Zhang et al, ).…”

Section: Discussionmentioning

confidence: 99%

Hsa_circ_0039411 promotes tumorigenesis and progression of papillary thyroid cancer by miR‐1179/ABCA9 and miR‐1205/MTA1 signaling pathways

Yang

Ding

et al. 2019

Journal Cellular Physiology

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Papillary thyroid cancer (PTC) is a common malignancy in endocrine system worldwide.Increasing evidence has shown that dysregulation of circular RNAs (circRNAs) could contribute to PTC tumorigenesis. The aims of this project are to investigate the potential role and molecular mechanism of hsa_circ_0039411 in PTC. In the project, RT-qPCR was performed to measure the expression profile of hsa_circ_0039411 in PTC tissues and cells.Cell counting kit-8, clonogenic, flow cytometric, and transwell experiments were used to identify the biological role of hsa_circ_0039411 on PTC cell progression. Bioinformatics methods, along with the dual-luciferase reporter test, was used to identify the potential mechanism of hsa_circ_0039411. Hsa_circ_0039411 was identified as enhanced in PTC tissues/cells. Gain-of-function experiments indicated that hsa_circ_0039411 facilitated PTC cell growth, migration, and invasion and inhibited cell apoptosis. Knockdown of hsa_circ_0039411 caused the opposite effects mentioned above. The mechanism exploration showed that hsa_circ_0039411 functioned as a sponge for miR-1179 and miR-1205 to elevate ATP-binding cassette transporter A9 (ABCA9) and metastasisassociated 1 (MTA1) expression at the post-transcriptional level, respectively. Further investigation confirmed that the functions of hsa_circ_0039411 are dependent on its modulation of ABCA9 and MTA1 in PTC cells. This study uncovered a mechanism of hsa_circ_0039411 in PTC, which might act as a novel therapeutic target for PTC. K E Y W O R D SATP-binding cassette transporter A9, circular RNA, hsa_circ_0039411, metastasis-associated 1, miR-1179, miR-1205, papillary thyroid cancer

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Section: Discussionmentioning

confidence: 99%

Hsa_circ_0039411 promotes tumorigenesis and progression of papillary thyroid cancer by miR‐1179/ABCA9 and miR‐1205/MTA1 signaling pathways

Yang

Ding

et al. 2019

Journal Cellular Physiology

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“…Increased levels of miR-142 have been shown to be associated with cardiovascular events (CVEs), especially with myocardial infarction [ 15 ], while miR-155, a macrophage-specific miRNA, is associated with inflammation in the context of atherosclerosis, as well as with the severity of CAD [ 16 , 17 ]. MiR-223 has been widely studied and shown to be involved in inflammation [ 18 ] and in the regulation of the lipid metabolism [ 19 ], and it has been shown to be upregulated in unstable atherosclerotic plaques from CAD patients [ 20 ]. MiR-92a is enriched in endothelial cells, where it mediates its communication with macrophages, thus contributing to atherosclerosis progression [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Increased miR-142 Levels in Plasma and Atherosclerotic Plaques from Peripheral Artery Disease Patients with Post-Surgery Cardiovascular Events

Barbalata

Moraru²,

Stancu

et al. 2020

IJMS

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There is an intensive effort to identify biomarkers to predict cardiovascular disease evolution. We aimed to determine the potential of microRNAs to predict the appearance of cardiovascular events (CVEs) in patients with peripheral artery disease (PAD) following femoral artery bypass surgery. Forty-seven PAD patients were enrolled and divided into two groups, without CVEs (n = 35) and with CVEs (n = 12), during 1 year follow-up. Intra-surgery atherosclerotic plaques from femoral arteries were collected and the levels of miR-142, miR-223, miR-155, and miR-92a of the primary transcripts of these microRNAs (pri-miRNAs), and gene expression of Drosha and Dicer were determined. Results showed that, in the plaques, miR-142, miR-223, and miR-155 expression levels were significantly increased in PAD patients with CVEs compared to those without CVEs. Positive correlations between these miRNAs and their pri-miRNAs levels and the Dicer/Drosha expression were observed. In the plasma of PAD patients with CVEs compared to those without CVEs, miR-223 and miR-142 were significantly increased. The multiple linear regression analyses revealed significant associations among several plasma lipids, oxidative and inflammatory parameters, and plasma miRNAs levels. Receiver operator characteristic (ROC) analysis disclosed that plasma miR-142 levels could be an independent predictor for CVEs in PAD patients. Functional bioinformatics analyses supported the role of these miRNAs in the regulation of biological processes associated with atherosclerosis. Taken together, these data suggest that plasma levels of miR-142, miR-223, miR-155, and miR-92a can significantly predict CVEs among PAD patients with good accuracy, and that plasma levels of miR-142 can be an independent biomarker to predict post-surgery CVEs development in PAD patients.

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“…There are various functional miRNAs that are associated with inflammatory disease progression by regulating the inflammatory response, including NS. For instance, miR-223 is an anti-inflammatory miRNA that is mainly expressed in myeloid cells ( 26 ). miR-144 was observed to induce autophagy and inflammatory responses in microglia after cerebral hemorrhage by regulating mTOR ( 27 ).…”

Section: Discussionmentioning

confidence: 99%

Downregulation of miR‑1184 serves as a diagnostic biomarker in neonatal sepsis and regulates LPS‑induced inflammatory response by inhibiting IL‑16 in monocytes

Wang

Han

2021

Exp Ther Med

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Neonatal sepsis (NS) remains a global problem. In the present study, abnormal expression of microRNA-1184 (miR-1184) was detected in neonates with NS and it was endeavored to investigate the diagnostic value of miR-1184, as well as its regulatory role in lipopolysaccharide (LPS)-induced inflammatory response in vitro. Furthermore, the correlation between interleukin-16 (IL-16) and miR-1184 was investigated to elucidate the pathological mechanisms of NS development. Reverse transcription-quantitative PCR was used to detect the expression of miR-1184. Receiver operating characteristic curve analysis was performed to evaluate the diagnostic value of miR-1184 in NS. Furthermore, a sepsis cell model was established by using LPS-induced monocytes to explore the effect of miR-1184 on the inflammatory response. The levels of inflammatory cytokines were determined by ELISA. A luciferase reporter assay was used to investigate the direct targeting interaction between miR-1184 and IL-16. The results indicated that the serum levels of miR-1184 in neonates with sepsis were decreased and miR-1184 had a high diagnostic value when differentiating NS from respiratory conditions in neonates. In vitro, the expression of miR-1184 in monocytes was inhibited by LPS and overexpression of miR-1184 reversed the effect of LPS to stimulate the inflammatory response. IL-16 was demonstrated to be a target of miR-1184 and a negative correlation between them was identified in patients with NS. The inflammatory response inhibited by miR-1184 mimics was enhanced by overexpression of IL-16 in LPS-induced monocytes. In conclusion, decreased levels of serum miR-1184 may be a potential diagnostic biomarker for NS. In addition, miR-1184 inhibited the LPS-induced inflammatory response by targeting IL-16 in monocytes, suggesting that the miR-1184/IL-16 axis may be a potential therapeutic target for NS.

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miRNA-223 at the crossroads of inflammation and cancer

Cited by 74 publications

References 76 publications

Hsa_circ_0039411 promotes tumorigenesis and progression of papillary thyroid cancer by miR‐1179/ABCA9 and miR‐1205/MTA1 signaling pathways

Hsa_circ_0039411 promotes tumorigenesis and progression of papillary thyroid cancer by miR‐1179/ABCA9 and miR‐1205/MTA1 signaling pathways

Increased miR-142 Levels in Plasma and Atherosclerotic Plaques from Peripheral Artery Disease Patients with Post-Surgery Cardiovascular Events

Downregulation of miR‑1184 serves as a diagnostic biomarker in neonatal sepsis and regulates LPS‑induced inflammatory response by inhibiting IL‑16 in monocytes

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