2016
DOI: 10.1186/s12877-016-0379-y
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Abstract: BackgroundIn mammals, the IGF-1 pathway affects the phenotype of aging. Since the function of the immune system is modulated by IGF-1, it is plausible that immunosenescence might in part result from altered control by this pathway. We therefore examined whether the expression of IGF-1R, FOXO1, and FOXO3a in peripheral blood mononuclear cells (PBMC) changes with age and if this might be due to changes in the expression of select miRNAs.MethodsThe expression of IGF-1R, FOXO1, FOXO3a, as well as of miR-9, miR-96,… Show more

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Cited by 27 publications
(16 citation statements)
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“…As we know, FOXO1 was a member of the FOXO family, which was widely distributed in human tissues and organs, such as heart, liver, prostate, peripheral blood, etc. [1720]. FOXO1 was an important tumor suppressor gene and was down-regulated in many types of tumors [21].…”
Section: Discussionmentioning
confidence: 99%
“…As we know, FOXO1 was a member of the FOXO family, which was widely distributed in human tissues and organs, such as heart, liver, prostate, peripheral blood, etc. [1720]. FOXO1 was an important tumor suppressor gene and was down-regulated in many types of tumors [21].…”
Section: Discussionmentioning
confidence: 99%
“…Thus, we speculate that the suppression of miR-96 to boost RAD51 expression by the bone morphogenetic protein–SMAD pathway may operate not only in pulmonary microvascular endothelial cells, but also in other cell types, whereby bone morphogenetic protein signaling would play a prevalent role as a guardian of genome integrity. Furthermore, miR-96 expression in peripheral blood mononuclear cells has been reported to increase upon aging 49 , suggesting that BMPR2 mutation carriers may experience a further age-dependent reduction of RAD51, which may correlate with pulmonary arterial hypertension progress with age. Finally, miR-96 has been classified as an oncogenic miRNA because its overexpression has been found in various tumors 50 .…”
Section: Discussionmentioning
confidence: 99%
“…Budzinska et al found that miR-96, miR-145, and expression were increased while IGF-1R was decreased in peripheral blood mononuclear cells of aging humans. The age-associated higher expression of miR-96 and miR-145 might contribute to the lower expression of IGF-1R [ 41 ]. In this study, we first investigated the relationship between miR-646 and IGF-1, revealing that IGF-1 was the direct target of miR-646 and there was a converse relationship between them.…”
Section: Discussionmentioning
confidence: 99%