2016
DOI: 10.18632/aging.100998
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Abstract: The reduction of DNA damage repair capacity in terminally differentiated cells may be involved in sensitivity to cancer chemotherapy drugs; however, the underlying molecular mechanism is still not fully understood. Herein, we evaluated the role of miR-638 in the regulation of DNA damage repair in terminally differentiated cells. Our results show that miR-638 expression was up-regulated during cellular terminal differentiation and involved in mediating DNA damage repair processes. Results from a luciferase repo… Show more

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Cited by 20 publications
(16 citation statements)
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References 71 publications
(86 reference statements)
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“…We have also shown a key role for the complex interplay between the DNA damage response and host immunity in determining risk for LUSC [ 84 ]. DNA damage has also long been regarded as one of the primary driving processes of aging contributing to genomic instability and some of the premature aging diseases are the consequence of accumulated DNA damage [ 85 , 86 ]. Further investigations into the link between mediators of the DDR and tumorigenesis and aging are required to de-lineate the mechanism of this important facet of NSCLC disease progression and premature aging diseases.…”
Section: Targeting the Ddr As A Mechanism In Tumorigenesismentioning
confidence: 99%
“…We have also shown a key role for the complex interplay between the DNA damage response and host immunity in determining risk for LUSC [ 84 ]. DNA damage has also long been regarded as one of the primary driving processes of aging contributing to genomic instability and some of the premature aging diseases are the consequence of accumulated DNA damage [ 85 , 86 ]. Further investigations into the link between mediators of the DDR and tumorigenesis and aging are required to de-lineate the mechanism of this important facet of NSCLC disease progression and premature aging diseases.…”
Section: Targeting the Ddr As A Mechanism In Tumorigenesismentioning
confidence: 99%
“…During the past few years, miR-638 has been identified as a promising tumor suppressor by targetedly regulating certain genes, such as SMC1A, MeCP2, and SOX2. [16][17][18] In addition, miR-638 may affect colorectal carcinogenesis, and progression by regulating the glycometabolism of cancer cells. 19 A recent study has reported that downregulation of miR-638 promotes angiogenesis and cell growth in HCC.…”
Section: Introductionmentioning
confidence: 99%
“…MiR‐638 is a primate‐specific miRNA that plays important roles in development, DNA damage repair, hematopoiesis, and leukemogenesis (M. He et al, ; Li et al, ; X. Lu, Chen, Chen, Shao, & Qin, ; Tan et al, ). In particular, the role of miR‐638 in cancer development has recently received a significant attention.…”
Section: Introductionmentioning
confidence: 99%