MiR-495 regulates proliferation and migration in NSCLC by targeting MTA3

Chu, Heying; Chen, Xudong; Wang, Huaqi; Du, Yuwen; Wang, Yuanyuan; Zang, Wenqiao; Li, Ping; Li, Juan; Chang, Jingxia; Zhao, Guoqiang; Zhang, Guojun

doi:10.1007/s13277-013-1460-1

Cited by 46 publications

(39 citation statements)

References 36 publications

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“…miR-495 is weakly expressed in prostate cancer and associated with prostate-specific antigen levels, lymph node invasion and Gleason scores (36). miR-495 is also downregulated in osteosarcoma (19), melanoma (20), endometrial cancer (21), acute myeloid leukaemia (22), renal cell carcinoma (37), breast cancer (38,39) and lung cancer (40,41). These findings suggested that miR-495 expression exhibits tissue specificity and may be a biomarker for these human cancers.…”

Section: Discussionmentioning

confidence: 96%

“…Lv et al found that restored miR-495 expression inhibits cell proliferation and motility and induces G0/G1 phase arrest in renal cell carcinoma (37). In lung cancer, miR-495 is involved in the regulation of cell proliferation, migration, epithelial-mesenchymal transition, chemosensitivity and chemoresistance (40,41,46). However, Tan et al indicated that miR-495 serves as an oncogene in bladder cancer through the regulation of cell proliferation and invasion (18).…”

Section: Discussionmentioning

confidence: 99%

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MicroRNA‑495 suppresses cell proliferation and invasion of hepatocellular carcinoma by directly targeting insulin‑like growth factor receptor‑1

Zhuang

Wang

et al. 2017

Exp Ther Med

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Abstract. Hepatocellular carcinoma (HCC) is the fifth most common malignancy and second-most frequent cause of cancer-associated deaths worldwide. Previously, increasing studies report that microRNAs (miRNAs/miRs) are abnormally expressed in various types of human cancers and may participate in the tumourigenesis and tumour development of HCC. miRNA-based targeted therapy is effective against different molecular targets and may increase the sensitisation of cancer cells to therapy by several folds. Therefore, further validation of potentially important miRNAs involved in HCC initiation and progression may provide valuable insights into the treatment of patients with HCC. miR-495 is abnormally expressed in multiple types of human cancers. However, the expression level and roles of miR-495 in HCC have yet to be completely elucidated. In the present study, miR-495 expression was frequently downregulated in HCC tissues and cell lines, and miR-495 expression levels were significantly correlated with tumour size, tumor-node-metastasis (TNM) stage and lymph node metastasis in patients with HCC. Functional assays revealed that miR-495 overexpression inhibited cell proliferation and invasion in HCC. Insulin-like growth factor receptor-1 (IGF1R) was identified as a direct target gene of miR-495 in HCC. IGF1R was upregulated in HCC tissues and negatively correlated with miR-495 expression level. The upregulation of IGF1R rescued the miR-495-induced tumour-suppressive roles in HCC cell proliferation and invasion, and the restored miR-495 expression inactivated the protein kinase B and extracellular regulated protein kinase signalling pathways in HCC. These results provide novel insights into the molecular mechanism underlying HCC progression, and suggest that miR-495 may be investigated as a novel therapeutic target for patients with this disease.

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Section: Discussionmentioning

confidence: 96%

Section: Discussionmentioning

confidence: 99%

MicroRNA‑495 suppresses cell proliferation and invasion of hepatocellular carcinoma by directly targeting insulin‑like growth factor receptor‑1

Zhuang

Wang

et al. 2017

Exp Ther Med

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“…Regarding the individual function of miR-410 and miR-495, a number of reports have linked both of these miRNAs to oncogenic pathways. Some studies have suggested a tumor suppressor role for these miRNAs (43)(44)(45), whereas others have indicated a pro-proliferative effect on tumor growth. Along these lines, miR-410 has been shown to be up-regulated in liver cancer and enhanced tumor cell growth (46).…”

Section: Discussionmentioning

confidence: 99%

MicroRNAs in the Myocyte Enhancer Factor 2 (MEF2)-regulated Gtl2-Dio3 Noncoding RNA Locus Promote Cardiomyocyte Proliferation by Targeting the Transcriptional Coactivator Cited2

Clark

Naya

2015

Journal of Biological Chemistry

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Background: MicroRNAs have recently emerged as key regulatory molecules in cardiomyocyte proliferation. Results: miR-410 and miR-495 are regulated by MEF2 in cardiomyocytes, and their overexpression results in increased cardiomyocyte proliferation. Conclusion: miR-410 and miR-495 potently induce cardiomyocyte proliferation by directly inhibiting the coactivator Cited2. Significance: These findings reveal novel microRNAs that can be modulated to stimulate the regeneration of damaged cardiac tissue.

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“…Accumulating evidence has indicated that miRNAs participate in a broad range of biological processes, such as proliferation, apoptosis, invasion and metastasis of different kind of tumors [8]. MiR-495, as a tumor-suppressive miRNA in most cases, has been shown to be under-expressed and to repress various target genes to inhibit the malignant processes of several types of tumor [9,10]. However, there are different views on the role of miR-495 in regulating tumor invasion and migration.…”

Section: Introductionmentioning

confidence: 99%

MicroRNA-495 suppresses osteosarcoma invasion and migration by targeting HSP90AA1

Xiao¹,

Wang²,

Li³

et al. 2018

Oncotarget

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MiR-495 is a tumor-suppressive microRNA that participates in tumor progression in human cancers. However, its expression and biological function in osteosarcoma remains unknown. In this study, we firstly found that miR-495 is markedly downregulated in both osteosarcoma tissues and cell lines. Then we demonstrated that miR-495 suppresses the invasion and metastasis of osteosarcoma cells in vitro through inhibiting epithelial to mesenchymal transition. Function of miR-495 in vivo was also examined in mice xenograft model and we found it significantly inhibiting the lung-metastasis of osteosarcoma cells. We also demonstrated that HSP90AA1 is a direct target of miR-495 using luciferase reporter assay and Western blot analysis. Furthermore, knockdown of HSP90AA1 can restore the increased cell invasion and migration in miR-495-knockdown cells and over expression of HSP90AA1 can neutralize the impaired metastatic ability of miR-495 mimic-treated cells. This metastasis-suppressive role of miR-495 in osteosarcoma is achieved by HSP90AA1-mediated PI3K/Akt/mTOR signaling pathway. Overall, our findings proved for the first time that miR-495 acts as a tumor suppressor in osteosarcoma and inhibits cell migration and invasion by targeting HSP90AA1, thus offering a promising therapeutic target for osteosarcoma treatment.www.impactjournals.com/oncotarget/

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MiR-495 regulates proliferation and migration in NSCLC by targeting MTA3

Cited by 46 publications

References 36 publications

MicroRNA‑495 suppresses cell proliferation and invasion of hepatocellular carcinoma by directly targeting insulin‑like growth factor receptor‑1

MicroRNA‑495 suppresses cell proliferation and invasion of hepatocellular carcinoma by directly targeting insulin‑like growth factor receptor‑1

MicroRNAs in the Myocyte Enhancer Factor 2 (MEF2)-regulated Gtl2-Dio3 Noncoding RNA Locus Promote Cardiomyocyte Proliferation by Targeting the Transcriptional Coactivator Cited2

MicroRNA-495 suppresses osteosarcoma invasion and migration by targeting HSP90AA1

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